{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:47:43Z","timestamp":1791856063853,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare maternal plasma afamin between pregnancies with fetal growth restriction (FGR) defined by fetal biometry and healthy controls, to test whether the cross\u2010sectional association between afamin and gestational age differs in FGR, and to examine associations with Doppler indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 84 women assessed at 28\u201340\u2009weeks (40 FGR, 44 controls) underwent same\u2010day maternal blood sampling and umbilical\u2010, middle\u2010cerebral\u2010, and uterine\u2010artery Doppler. FGR was defined by an estimated fetal weight or abdominal circumference below the 5th percentile. Plasma afamin was measured by enzyme\u2010linked immunosorbent assay. Analyses included a group\u2010by\u2010gestational\u2010age interaction model, multivariable logistic regression, adjusted partial correlations, and receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Afamin was higher in FGR than controls (109.6\u2009\u00b1\u20095.8 vs. 98.2\u2009\u00b1\u20099.4\u2009mg\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), persisting after adjustment (adjusted difference 11.2\u2009mg\/L). In controls, afamin was strongly associated with gestational age (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.95), whereas in FGR it was not (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.03); the group\u2010by\u2010gestational\u2010age interaction was significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Afamin was associated with FGR after adjustment (odds ratio 4.99 per 5\u2009mg\/L), an effect concentrated before 34\u2009weeks. Pooled afamin\u2013Doppler (Spearman) correlations did not remain significant after adjustment for group. Afamin did not correlate with body mass index. The area under the curve was 0.837.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In biometrically defined FGR, plasma afamin was elevated and, unlike in controls, was not associated with gestational age. Afamin was associated with FGR after covariate adjustment, but its strength varied with gestational age; these cross\u2010sectional, exploratory findings require validation before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70524","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:49:37Z","timestamp":1791787777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Plasma Afamin Levels in Pregnancies Complicated by Fetal Growth Restriction and Their Association With Doppler Markers of Placental Dysfunction"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4009-6719","authenticated-orcid":false,"given":"Emrah","family":"G\u00f6\u00e7er","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kayseri City Hospital  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-4312","authenticated-orcid":false,"given":"Kadriye Yakut","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Perinatology Etlik Z\u00fcbeyde Han\u0131m Women's Health Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3242-025X","authenticated-orcid":false,"given":"Cemal","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Special Clinic  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-1353","authenticated-orcid":false,"given":"Harika","family":"G\u00f6\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kayseri City Hospital  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-3474","authenticated-orcid":false,"given":"\u015eevki","family":"\u00c7elen","sequence":"additional","affiliation":[{"name":"Department of Perinatology Etlik Z\u00fcbeyde Han\u0131m Women's Health Training and Research Hospital  Ankara 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