{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:39:29Z","timestamp":1792381169583,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of an estriol\u2010lactobacilli combination vaginal tablet (E3\/L) and polycarbophil\u2010based vaginal moisturizer (PBVM) in women with post\u2010radiation vaginitis following cervical cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This open\u2010label, randomized controlled trial recruited 34 women with Stages I\u2013III cervical cancer who had completed pelvic radiotherapy and developed vaginal toxicity symptoms. Participants were randomized 1:1 to E3\/L (Gynoflor) or PBVM (Regelle) for 4\u2009weeks. The primary outcome was change in vaginal maturation value (VMV). Secondary outcomes included changes in vaginal pH, vaginal toxicity symptom scores, and Female Sexual Function Index (FSFI) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median improvement in VMV was significantly greater with E3\/L than with PBVM (19.65 [IQR: 0\u201339.5] vs. 2.08 [IQR: 0\u201320.1] points;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035; 95% CI: 10.22\u201332.59). Vaginal dryness and inflammation improved significantly in the E3\/L group. Changes in vaginal pH, dyspareunia, and vaginal pain were similar between groups. Although the FSFI change was greater with E3\/L (median +6 vs. +2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), absolute FSFI scores at Week 4 were similar, and clinical significance is uncertain. Both treatments were well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In women with cervical cancer and radiation\u2010induced vaginitis, E3\/L showed greater short\u2010term improvements in vaginal epithelial maturation, dryness, and inflammation than PBVM over 4\u2009weeks. These findings are exploratory given the modest sample size, open\u2010label design, and short follow\u2010up; larger double\u2010blind randomized trials with extended follow\u2010up are needed to confirm these results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Thai Clinical Trials Registry: TCTR2024051001<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70525","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:17:17Z","timestamp":1791292637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Estriol\u2010Lactobacilli Combination Versus Polycarbophil\u2010Based Vaginal Moisturizer on Post\u2010Radiation Vaginitis in Women With Cervical Cancer: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9511-7457","authenticated-orcid":false,"given":"Natcha","family":"Koohachaiskun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-8236","authenticated-orcid":false,"given":"Thiti","family":"Atjimakul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4263-5226","authenticated-orcid":false,"given":"Krantarat","family":"Peeyananjarassri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-1216","authenticated-orcid":false,"given":"Satit","family":"Klangsin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-0751","authenticated-orcid":false,"given":"Kanet","family":"Kanjanapradit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2025.100397"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2023.24.5.1759"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57040336"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60101584"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.680038"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18083932"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08274-w"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.769097"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2447-1"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-001034"},{"issue":"5","key":"e_1_2_13_12_1","first-page":"625","article-title":"Sexual Functioning in Postmenopausal Women Not Taking Hormone Therapy in the Gynecological and Menopause Clinic, Songklanagarind Hospital Measured by Female Sexual Function Index Questionnaire","volume":"91","author":"Peeyananjarassri K.","year":"2008","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2011.57"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2930-x"}],"container-title":["Journal of Obstetrics and Gynaecology 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