{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:41:21Z","timestamp":1792651281394,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To develop and internally validate a pretreatment quantitative magnetic resonance imaging\u2010based predictive model for uterine fibroid volume reduction following gonadotropin\u2010releasing hormone antagonist therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective study, 106 women with uterine fibroids treated with relugolix underwent pre\u2010 and intratreatment magnetic resonance imaging. The dominant fibroid was assessed for T2\u2010weighted imaging fibroid\u2010to\u2010iliopsoas signal intensity ratio, apparent diffusion coefficient, flow voids, and fibroid location. The primary outcome was a \u2265\u200930% reduction in dominant fibroid volume between pre and intratreatment magnetic resonance imaging. Eight baseline variables were entered into a Least Absolute Shrinkage and Selection Operator\u2010penalized logistic regression model with bootstrap internal validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty patients (56.6%) achieved a \u2265\u200930% volume reduction. In the univariate analyses, a higher T2\u2010weighted imaging signal intensity ratio and location were significantly associated with response. A purely data\u2010driven Least Absolute Shrinkage and Selection Operator model retained two predictors: dichotomized T2\u2010weighted imaging signal intensity ratio and location. A T2\u2010weighted imaging ratio \u2265\u20092.0 was the strongest positive predictor, whereas subserosal and cervical locations showed negative associations and submucosal location showed a slight positive association relative to intramural fibroids. The model showed moderate discrimination (apparent area under the receiver operating characteristic curve, 0.746; optimism\u2010corrected area, 0.671) with acceptable calibration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quantitative pretreatment T2\u2010weighted imaging (ratio\u2009\u2265\u20092.0) is strongly associated with fibroid volume reduction under gonadotropin\u2010releasing hormone antagonist therapy. An internally validated Least Absolute Shrinkage and Selection Operator\u2010based model incorporating T2\u2010weighted imaging signal intensity and location may aid individualized treatment selection and preoperative planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70530","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:09:31Z","timestamp":1792649371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized Prediction of Uterine Fibroid Shrinkage During\n                    <scp>GnRH<\/scp>\n                    Antagonist Treatment via Pretreatment\n                    <scp>T2<\/scp>\n                    \u2010Weighted\n                    <scp>MRI<\/scp>\n                    Signal Intensity"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0338-3622","authenticated-orcid":false,"given":"Shigenobu","family":"Motoshima","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nomiyama","sequence":"additional","affiliation":[{"name":"Department of Radiology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-8290","authenticated-orcid":false,"given":"Kenyu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3083-9375","authenticated-orcid":false,"given":"Hideyuki","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-9365","authenticated-orcid":false,"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Biostatistics Center Kurume University  Kurume Japan"},{"name":"School of Medical Technology Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-0455","authenticated-orcid":false,"given":"Kosuke","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-6160","authenticated-orcid":false,"given":"Hiroki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naofumi","family":"Okura","sequence":"additional","affiliation":[{"name":"Tobata Kyoritsu Hospital  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-4091","authenticated-orcid":false,"given":"Toshiyuki","family":"Yoshizato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology NHO Kokura Medical Center  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"22481","DOI":"10.1038\/s41598-024-73151-y","article-title":"Presurgical Treatment of Uterine Myomas With the GnRH\u2010Antagonist Relugolix in Combination Therapy: An Observational Study","volume":"14","author":"Muzii L.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jmig.2021.12.011","article-title":"Oral Gonadotropin\u2010Releasing Hormone Antagonists in the Treatment of Uterine Myomas: A Systematic Review and Network Meta\u2010Analysis of Efficacy Parameters and Adverse Effects","volume":"29","author":"Telek S. 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