{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:54:39Z","timestamp":1782950079847,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T00:00:00Z","timestamp":1353283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent studies have suggested the existence of a late catch\u2010up phenomenon after drug\u2010eluting stent (DES) implantation. The aim of this study is to identify predictors of early (\u22641 year) and late (&gt;1 year) target lesion revascularization (TLR) in DESs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The COACT (CathOlic medical center percutAneous Coronary inTervention) registry was designed to evaluate the clinical outcomes after DES implantation. Data from 9,127 consecutive patients were reviewed, all of whom underwent percutaneous coronary intervention (PCI) with DES between January 2004 and December 2009, including 8,126 patients who received PCI with homogenous DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up period of 24 months (interquartile range, 11\u201341), the cumulative incidences of early and late TLR were 4.7% (95% confidence interval [CI], 4.2\u20135.1) and 3.3% (95% CI, 2.9\u20133.7). Independent predictors of early TLR were multivessel disease (odds ratio [OR] 1.637; 95% CI 1.241\u20132.158, P &lt; 0.001) and stent diameter (OR 0.614; 95% CI 0.437\u20130.862, P = 0.005). Independent predictors of late TLR were stent diameter (OR 0.567; 95% CI 0.367\u20130.875, P = 0.010), insulin\u2010dependent diabetes mellitus (OR 2.235; 95% CI 1.314\u20133.802, P = 0.003), first\u2010generation DES (OR 5.104; 95% CI 2.744\u20139.492, P &lt; 0.001), and elevated levels of high\u2010sensitivity C\u2010reactive protein at follow\u2010up coronary angiography &gt;2 mg\/dL (OR 1.616; 95% CI 1.173\u20132.226, P = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although multivessel disease and stent diameter were associated with early TLR, late TLR was more associated with clinical comorbidities including insulin\u2010dependent diabetes and procedural factors like the generation of the stent used and stent diameter. The risk factors for TLR may be markedly different at different time points during TLR.  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