{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:29:25Z","timestamp":1770985765018,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T00:00:00Z","timestamp":1353283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although it has been demonstrated that cardiac remodeling and exercise capacity improve after transcatheter closure of atrial septal defect (ASD), little is known about long\u2010term benefits in middle\u2010aged and elderly patients with a reduction in cardiopulmonary function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate long\u2010term extent and time course of improvements in cardiac remodeling and exercise capacity in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Twenty ASD patients \u2265 40 years of age with a reduction in cardiopulmonary function (predicted peak oxygen uptake [VO<jats:sub>2<\/jats:sub>] &lt; 65%) were enrolled. Transthoracic echocardiography and cardiopulmonary exercise testing were performed at baseline and at 1 month, 3 months, 6 months, and &gt;12 months after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1 month after the procedure, significant decreases in right ventricular (RV) end\u2010diastolic diameter (38.2 \u00b1 4.4 to 31.9 \u00b1 4.4 mm; P &lt; 0.001) and RV\/left ventricular end\u2010diastolic diameter ratio (0.95 \u00b1 0.17 to 0.71 \u00b1 0.13; P &lt; 0.001) occurred, and they were maintained during the follow\u2010up period. Normal RV size was achieved in 11 of 18 patients with RV enlargement. Predicted peak VO<jats:sub>2<\/jats:sub> did not change at 1 month and 3 months, but it improved significantly after 6 months (53.6 \u00b1 6.5 to 62.1 \u00b1 12.6%; P &lt; 0.01). Sixteen of the 20 patients showed improved predicted peak VO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiac remodeling and exercise capacity could be improved over the long\u2010term period after transcatheter closure of ASD in middle\u2010aged and elderly patients with a reduction in cardiopulmonary function. There were differences in the time course of improvement between cardiac remodeling and exercise capacity in those patients. 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