{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:28:00Z","timestamp":1782433680534,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>We aimed to determine the optimal adjunctive anticoagulation regimen for percutaneous coronary intervention (PCI) in patients presenting with acute coronary syndrome (ACS) initially treated with fondaparinux<\/jats:italic>. <jats:italic>The optimal adjunctive anticoagulation regimen for PCI in these patients is unclear. In this open\u2010label, prospective, randomized, multicenter pilot study, we compared treatment with unfractionated heparin (UFH) versus bivalirudin in patients with non\u2010ST\u2010segment elevation ACS initially treated with fondaparinux and undergoing early invasive strategy. The randomized population consisted of 100 patients (62.7 \u00b1 12.7 years, 68% men), all of whom were on clopidogrel. During the angioplasty, patients were randomized to either bivalirudin or UFH therapy in a 1:1 fashion. Baseline clinical and angiographic characteristics were similar except for a higher body mass index in the UFH group (29.4 \u00b1 4.7 vs. 27.3 \u00b1 4.2, P = 0.02). Major bleeding was the primary outcome; a major bleeding event was documented in only 1 patient from the bivalirudin group (2%) and in none from the UFH group (P = 0.49). There was no death, Q\u2010wave MI, or acute revascularization in either group. There was no documentation of stent thrombosis, reinfarction, and catheter thrombus. Data from this prospective, multicenter pilot study suggest that bivalirudin, compared to standard\u2010dose UFH, has a similar safety profile in terms of peri\u2010PCI bleeding and thrombotic events and can be used safely in ACS patients initially treated with upstream fondaparinux who undergo PCI.<\/jats:italic> (J Interven Cardiol 2013;26:107\u2013113)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12005","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T03:32:51Z","timestamp":1355455971000},"page":"107-113","source":"Crossref","is-referenced-by-count":30,"title":["Bivalirudin versus Unfractionated Heparin during Percutaneous Coronary Intervention in Patients with Non\u2010ST\u2010Segment Elevation Acute Coronary Syndrome Initially Treated with Fondaparinux: Results from an International, Multicenter, Randomized Pilot Study (SWITCH III)"],"prefix":"10.1111","volume":"26","author":[{"given":"RON","family":"WAKSMAN","sequence":"first","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OLIVIER","family":"BERTRAND","sequence":"additional","affiliation":[{"name":"Laval Hospital Quebec Heart and Lung Institute Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MITCHELL","family":"DRIESMAN","sequence":"additional","affiliation":[{"name":"Bridgeport Hospital Bridgeport Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS","family":"GRUBERG","sequence":"additional","affiliation":[{"name":"Stony Brook University Medical Center Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSEPH","family":"ROSSI","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHAMIR","family":"MEHTA","sequence":"additional","affiliation":[{"name":"Hamilton General Hospital Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STACY","family":"SWYMELAR","sequence":"additional","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANNY","family":"DVIR","sequence":"additional","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHENYI","family":"XUE","sequence":"additional","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REBECCA","family":"TORGUSON","sequence":"additional","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0691"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.051"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055443"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.joc60038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.188208"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr236"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1320"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062437"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.6.696"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708191"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109596"},{"key":"e_1_2_7_13_1","first-page":"370","article-title":"Switching from enoxaparin to bivalirudin in patients with acute coronary syndromes without ST\u2010segment elevation who undergo percutaneous coronary intervention. 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