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To date, these DES have virtually replaced the use of first\u2010generation DES worldwide. In this review article, we carefully consider the pre\u2010clinical and clinical trials that have been performed with currently available, european conformity\u2010marked and Food and Drug Administration\u2013approved new\u2010generation Resolute<\/jats:italic><jats:sup><jats:italic>\u00ae<\/jats:italic><\/jats:sup> <jats:italic>and Xience V<\/jats:italic><jats:sup><jats:italic>\u00ae<\/jats:italic><\/jats:sup> <jats:italic>DES<\/jats:italic>. 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