{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:45:32Z","timestamp":1696571132922},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the safety and efficacy of everolimus\u2010eluting stents (EES) to first\u2010generation drug\u2010eluting stents (DES) in multivessel disease (MVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Second\u2010generation EES have demonstrated superiority over first\u2010generation DES for single\u2010vessel disease, although the merits of EES in MVD are less established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 1,285 patients (3,124 lesions) with \u22652 diseased vessels were treated with either first\u2010generation DES (n\u2009=\u20091,002) or EES (n\u2009=\u2009283). The rates of death, myocardial infarction, target lesion revascularization, target vessel revascularization, definite stent thrombosis, and major adverse cardiac events (MACE), defined as the combined incidence of target vessel revascularization, death, and non\u2010fatal myocardial infarction, were compared at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were similar except for a lower left ventricular ejection fraction and a lower incidence of stable angina pectoris in the first\u2010generation DES group (P\u2009=\u20090.001 and 0.013, respectively). At 1 year, the MACE rate was lower in the EES group (9.5P% vs. 15.7%; P\u2009=\u20090.01). Multivariable analysis demonstrated that EES use predicted a higher chance of freedom from MACE at 1 year (hazard ratio 0.58 [0.38\u20130.87]; P\u2009=\u20090.009; 95% confidence interval).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of EES in patients with MVD is safe with signals for improved effectiveness compared to first\u2010generation DES. Randomized trials comparing new\u2010generation DES to coronary artery bypass grafting surgery are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12063","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T06:50:40Z","timestamp":1379055040000},"page":"561-569","source":"Crossref","is-referenced-by-count":3,"title":["Second\u2010<scp>G<\/scp>eneration Everolimus\u2010<scp>E<\/scp>luting Stents Compared to First\u2010<scp>G<\/scp>eneration Drug\u2010<scp>E<\/scp>luting Stents in Patients Treated for Multivessel Disease"],"prefix":"10.1111","volume":"26","author":[{"given":"SA'AR","family":"MINHA","sequence":"first","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ISRAEL M.","family":"BARBASH","sequence":"additional","affiliation":[{"name":"Interventional Cardiology MedStar Washington Hospital Center Washington 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