{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:22:03Z","timestamp":1761765723811},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T00:00:00Z","timestamp":1384300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Federation Fran\u00e7aise de Cardiologie (FFC)-Association de Cardiologie Ile de France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to determine the rate and potential clinical impact of persistent platelet reactivity (PPR) in unprotected left main (ULMD) stenting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PPR under aspirin or thienopyridines is associated with acute events after angioplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively included 125 patients referred for ULMD stenting. For the first 64 patients (ALMA\u20101), angioplasty was performed under aspirin and clopidogrel without platelet reactivity assessment. For the last 61 patients (ALMA\u20102), platelet reactivity was assessed before angioplasty: in patients with aspirin\u2010related PPR, aspirin twice daily was given and in those with clopidogrel\u2010related PPR, clopidogrel double dose or prasugrel was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, patients' mean age was 69\u2009\u00b1\u200913 years, 37% were diabetic, and 37% had non\u2010ST segment elevation myocardial infarction (NSTEMI). Patients' characteristics were similar in both studies with isolated left main in 14% and associated with 1\u2010, 2\u2010, or 3\u2010vessel disease in 23%, 36%, and 27%, respectively. Mean SYNTAX score was 23\u2009\u00b1\u20099. Procedural characteristics were similar using provisional T stenting in 69%, T stenting in 27%, and other techniques in 4%. In ALMA\u20102, 28% patients had PPR for aspirin, 29% for clopidogrel, and 8% for both. Aspirin twice daily was given in 28% of patients, clopidogrel double dose in 26%, and prasugrel in 31%. The rate of 1\u2010year major adverse cardiovascular and cerebrovascular events (MACCE) was lower in ALMA\u20102 versus ALMA\u20101 (8.2% vs. 20.8%; P\u2009=\u20090.04) as a composite end\u2010point of cardiovascular death or stent thrombosis (0.0% vs. 8.3%; P\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPR under aspirin and thienopyridines is frequent in ULMD stenting and could be related to subsequent major events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12076","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T02:52:41Z","timestamp":1384397561000},"page":"578-585","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring Persistent Platelet Reactivity in Patients with Unprotected Left Main Stenting"],"prefix":"10.1111","volume":"26","author":[{"given":"JEAN\u2010GUILLAUME","family":"DILLINGER","sequence":"first","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGIOS","family":"SIDERIS","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IHEB","family":"KCHAOU","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLAIRE","family":"BAL DIT SOLLIER","sequence":"additional","affiliation":[{"name":"Angio\u2010hematology and IVS\u2010Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHANE","family":"MANZO SILBERMAN","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SEBASTIAN","family":"VOICU","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIKOLAOS","family":"MAGKOUTIS","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAMIEN","family":"LOGEART","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUDOVIC","family":"DROUET","sequence":"additional","affiliation":[{"name":"Angio\u2010hematology and IVS\u2010Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRICK","family":"HENRY","sequence":"additional","affiliation":[{"name":"Department of Cardiology Inserm U942, Lariboisiere Hospital, AP\u2010HP\u2010Paris Diderot University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ALMA (Angioplasty of Left Main \u2013 lAriboisiere) 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