{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:00:05Z","timestamp":1785376805729,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Evidences concerning the predictive value of baseline inflammatory biomarkers after drug\u2010eluting stent (DES) placement are controversial, mainly because the use of statin was not precisely defined<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>The aim was to compare the differences between interleukin (IL)\u20106 and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) in predicting cardiovascular events 2 years after stenting in patients with unstable angina (UA) who had not received statin pretreatment<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>There were 1,896 patients included in this study. The primary end\u2010point was the occurrence of cardiac death or myocardial infarction (MI). Secondary endpoints included all\u2010cause death, stent thrombosis (ST), target lesion revascularization (TLR), target vessel revascularization (TVR), or a composite of major adverse cardiac events (MACE) at 2 years after the procedure<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>During the median follow\u2010up of 2.77 years, 96 patients experienced cardiac death (n\u2009=\u200937, 1.95%) or MIs (n\u2009=\u200970, 3.69%), 94 TLRs, 123 TVRs, 215 MACEs, and 21 definite or probable STs. In multivariable Cox proportional\u2010hazards models and discrimination analysis, elevated IL\u20106 levels were superior to hs\u2010CRP in predicting the occurrence not only of cardiac death or MI (HR 1.337, 95% CI 1.234\u20131.449, P\u2009&lt;\u20090.001), but also of MACE and late\u2010occurring definite\/probable ST. Incorporation of IL\u20106 into conventional variables resulted in significantly increased c statistic for the prediction of end\u2010points, with the exception of TLR and TVR<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Elevated IL\u20106 levels were independent predictors of cardiac death or MI, MACE, and late ST in patients with UA who had not received statin pretreatment, suggesting a role for IL\u20106 in the inflammatory risk assessment. Pathological studies have confirmed that atherosclerosis is a chronic inflammatory disease. Serum levels of high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), matrix metalloproteinase, plasminogen activator inhibitor\u20101, the complement components C3a or C5a, and interleukin(IL)\u20106 were reported to provide strong and independent indications of the risk for future cardiovascular (CV) events, even among individuals who are thought to be free of vascular disease<\/jats:italic>. (J Interven Cardiol 2014;27:142\u2013154)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12103","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T12:26:47Z","timestamp":1393936007000},"page":"142-154","source":"Crossref","is-referenced-by-count":16,"title":["Interleukin\u20106, but Not C\u2010Reactive Protein, Predicts the Occurrence of Cardiovascular Events after Drug\u2010Eluting Stent for Unstable Angina"],"prefix":"10.1111","volume":"27","author":[{"given":"SHAO\u2010LIANG","family":"CHEN","sequence":"first","affiliation":[{"name":"Nanjing First Hospital Nanjing Medical University Nanjing China"},{"name":"Gansu Provincial People's Hospital Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAN","family":"LIU","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital Nanjing Medical University Nanjing 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