{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:35:47Z","timestamp":1780500947694,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>The aim of this study was to assess prospectively the effectiveness and safety profile of distal left main stem (LMS) stenosis treatment with dedicated bifurcation paclitaxel\u2010eluting stent BiOSS Expert\u00ae<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Angioplasty of distal LMS stenosis is always a high\u2010risk procedure, and optimal treatment is uncertain<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>This was a prospective international 2\u2010center study, which enrolled patients with non\u2010ST\u2010elevation acute coronary syndrome (NSTE\u2010ACS) or stable angina with distal left main stenosis. All patients were treated with the dedicated bifurcation stent BiOSS Expert\u00ae. Provisional T\u2010stenting was the obligatory strategy. Angiographic control was performed after 12 months. The primary end\u2010point was cumulative rate of death, myocardial infarction (MI), and target lesion revascularization (TLR) at 12 months. Angiographic end\u2010points included late lumen loss, percent diameter stenosis, and binary restenosis rate<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>A total of 54 patients with distal LMS stenosis were enrolled. Seven patients (13%) were enrolled during NSTE\u2010ACS, 77.8% were hypertensive, 27.8% were diabetic, 51.9% had previous MI, 53.7% underwent prior percutaneous coronary intervention, and 16.7% coronary artery bypass graft. The mean SYNTAX score was 21.52\u2009\u00b1\u20096.50. The device success rate was 100%. The mean BiOSS Expert stent parameters were as follows: 4.07\u2009\u00b1\u20090.26\u2009mm\u2009\u00d7\u20093.36\u2009\u00b1\u20090.26\u2009mm\u2009\u00d7\u200916.61\u2009\u00b1\u20091.72\u2009mm and in side branch the other stent (classical drug\u2010eluting stent) was implanted in 25.9% of cases. The overall TLR was 9.3%. There were no death, stent thrombosis, or acute MI. In the univariate regression analysis, the only factor associated with higher risk for TLR was the SYNTAX score value<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>The dedicated bifurcation stent BiOSS Expert\u00ae proved to be a feasible device, with promising safety and long\u2010term clinical effectiveness in the treatment of distal LMS stenosis<\/jats:italic>. 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