{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:02:06Z","timestamp":1761102126566},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>The authors investigated safety and efficacy of the MitraClip\u2010System (MCS) using a systematic analysis<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>The safety and efficacy of the MCS continues to be debated, and randomized trials are still lacking<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:italic>A systematic literature search was conducted using common medical and scientific databases. The following kinds of data were obtained: at baseline, 30 days, 6 and 12 month post\u2010procedure. For safety and efficacy mortality\u2010rate (survival), mitral regurgitation &lt;2+ (MR), adverse event rate (AE), NYHA class and reoperation\u2010rate were documented. A meta\u2010analysis with quantitative summary was performed<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Twenty\u2010six studies including 3821 patient's who were treated with MCS, were analyzed. Weighted mean age was 73.9\u2009\u00b1\u20092.3 years and LogEuroScore was 25.2\u2009\u00b1\u20096.0%. Post\u2010procedural MR&lt;2+ was achieved in 86.4% and 66.3% of the patients were in NYHA class I\/II within 30 days, AE\u2010rate was 18.3%, mortality\u2010rate was 2.8% and reoperation\u2010rate was 3.5%. Freedom from MR&gt;3\u2009+\u2009\u22124 was 80.2% (80.1%), from NYHA III\/IV was 78.6% (66.1%) and freedom from death was 82.6% (87.8%) and from reoperation 95.6% (88.6%) at 6 and 12 month<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Based on the analysis of the current literature treatment with MCS is associated with good short\u2010term success and low mortality. MCS is safe and effective for patients with limited surgical options. The results are comparable with open mitral valve repair (oMVR) but patients are markedly older and have a higer risk profile than patients who undergo oMVR. Prospective randomized controlled trials are warranted to determine potential AEs, device durability and long\u2010term follow\u2010up<\/jats:italic>. (J Interven Cardiol 2015;28:69\u201375)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12168","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T10:43:56Z","timestamp":1424083436000},"page":"69-75","source":"Crossref","is-referenced-by-count":9,"title":["(Meta)\u2010Analysis of Safety and Efficacy Following Edge\u2010to\u2010Edge Mitral Valve Repair Using the MitraClip System"],"prefix":"10.1111","volume":"28","author":[{"given":"DOROTHEE H.L.","family":"BAIL","sequence":"first","affiliation":[{"name":"Competence\u2010Center Quality Assurance Medical Service of Statutory Healthcare Insurance Tuebingen and Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.1022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.04.009"},{"key":"e_1_2_8_4_1","article-title":"Moderne Mitral\u2010und Trikuspidalklappenchirurgie","author":"Conradi L","year":"2008","journal-title":"Clin Res Cardiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.084"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.06.034"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.07.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs076"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2013.0326"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2014.0017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2013.0325"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_8_14_1","unstructured":"EisendM.Meta\u2010Analyse: Einf\u00fchrung und kritische Diskussion. http:\/\/www.econstor eu\/bitstream\/10419\/49908\/1\/668827637.pdf\u2010Access:15\u201011\u20102013 2004."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24586"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I5A88"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"Bonow RO Carabello BA Kanu C et al. ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 2006;114:e84\u2013231.","DOI":"10.1161\/CIRCULATIONAHA.106.177303"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.03.089"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.11.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq331"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq222"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.076109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.802314"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2007.04.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs078"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634436"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.13-00243"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2011.09.002"},{"key":"e_1_2_8_30_1","first-page":"265","article-title":"Mitral valve repair versus replacement in the elderly population","volume":"20","author":"Markar SR","year":"2011","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312808"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.044"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.042"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.117277"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2007.05.002"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.07.034"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.01.017"},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"I402","DOI":"10.1161\/CIRCULATIONAHA.104.525188","article-title":"Mitral valve repair for functional mitral regurgitation in end\u2010stage dilated cardiomyopathy: Role of the \u201cedge\u2010to\u2010edge\u201c technique","volume":"112","author":"De Bonis M.","year":"2005","journal-title":"Circulation"},{"key":"e_1_2_8_39_1","first-page":"181","article-title":"Surgical isolated edge\u2010to\u2010edge mitral valve repair without annuloplasty: Clinical proof of the principle for an endovascular approach","volume":"2","author":"Maisano F","year":"2006","journal-title":"EuroIntervention"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.05.045"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1322621"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.05.067"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12181-013-0492-5"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12181-013-0488-1"},{"key":"e_1_2_8_46_1","first-page":"18","article-title":"The mitraClip system: A systematic review of indications, procedural requirements, and guidelines","volume":"62","author":"Bail DH","year":"2014","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1101009"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2011.09.001"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-011-9833-2"},{"key":"e_1_2_8_50_1","first-page":"679","article-title":"Meta\u2010analysis protocol: MitraClip system versus surgery for treatment of severe mitral regurgitation","volume":"2","author":"Wan B","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht381"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt036"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.05.105"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.070"},{"key":"e_1_2_8_55_1","first-page":"354","article-title":"Long\u2010term outcomes of early surgery for asymptomatic severe chronic mitral regurgitation","volume":"22","author":"Tabata M","year":"2013","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25347"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2007.12.005"},{"key":"e_1_2_8_59_1","unstructured":"NHC. 2011. Transcatheter mitral valve repair for severe mitral valve regurgitation. National health commitee \u2010 New Zealand ;1\u20138."},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.11.039"},{"key":"e_1_2_8_61_1","first-page":"1225","article-title":"A systematic review and meta\u2010analysis of surgical outcomes following mitral valve surgery in octogenarians: Implications for transcatheter mitral valve interventions","volume":"22","author":"Andalib A","year":"2013","journal-title":"EuroIntervention"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.11.019"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0806111"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.009"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.093"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.05.056"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.061"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.030"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12051"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.07.020"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joic.12168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:22:29Z","timestamp":1696508549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joic.12168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/joic.12168"],"URL":"https:\/\/doi.org\/10.1111\/joic.12168","archive":["Portico"],"relation":{},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}