{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:16:04Z","timestamp":1777104964251,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>To assess outcomes for MitraClip therapy in patients with refractory heart failure (HF) and mitral regurgitation (MR) \u22653+<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>The beneficial role of Mitraclip also in patients with severe HF has been reported<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Out of 45 patients undergoing MitraClip implantation at our institute, 16 were on refractory HF defined as diuretics and\/or inotropics infusion and\/or IABP dependence (group A) or labile haemodynamic balance (group B)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Patients were aged 69\u2009\u00b1\u200913 years and 75% were males. Group A (8 patients) had a mean hospitalization length before MitraClip procedure of 5333 days. Group B (8 patients) had a mean rate of hospitalization, in the last 50 days before procedure, of 254 days. Acute procedural success was observed in 94% of patients. All but one patients of group A were quickly weaned from pharmacologic and\/or mechanical supports within 5\u2009\u00b1\u20093 days from procedure and discharged at 20\u00b110 days. All patients of group B were discharged after 10\u00b18 days from MitraClip. At 1 year: a) cumulative survival rate was 78%; b) all patients were in NYHA functional class\u2009\u2264\u2009II; c) residual MR\u2009\u2264\u20092 was observed in 90%; d) systolic pulmonary arterial pressure was significantly reduced compared to the baseline (from 5410 to 398; p\u2009=\u20090,008); e) significant reduction of cumulative HF hospitalization days in the post\u2010procedure year (10 days) compared to the pre\u2010implantation year (280 days; p\u2009=\u20090.023) was observed<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>In patients with refractory HF and MR \u22653+, MitraClip implantation resulted in acute and persistent clinical benefit and net reduction of HF re\u2010hospitalization<\/jats:italic>. 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