{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:41:57Z","timestamp":1777430517561,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed at comparing direct stenting (DS) versus stenting with pre\u2010dilation (SP) in patients with ST\u2010elevation myocardial infarction (STEMI), using a systematic review and meta\u2010analysis of published evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>There is conflicting evidence whether stenting strategy impacts clinical outcomes in patients with STEMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched EMBASE, MEDLINE, and CENTRAL, from inception to December 2014. The primary endpoint was mortality. Secondary endpoints included major adverse cardiac events (MACEs), ST\u2010segment resolution, and angiographic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 9,331 patients enrolled in 12 studies (3 randomized controlled trials, RCTs; 9 non\u2010randomized studies, NRSs) were included. DS was associated with lower mortality (OR 0.55; 95%CI: 0.33\u20130.94; P\u2009=\u20090.03) in NRSs, and overall (OR 0.56; 95%CI: 0.37\u20130.86; P\u2009=\u20090.008). Mortality was non\u2010significantly reduced in RCTs (OR 0.56; 95%CI: 0.26\u20131.23; P\u2009=\u20090.15). DS was also associated with lower MACE rate (OR 0.71; 95%CI 0.60\u20130.84; P\u2009&lt;\u20090.0001) in NRSs, but not in RCTs (OR 0.99; 95%CI: 0.61\u20131.60; P\u2009=\u20090.96). ST\u2010segment resolution, no reflow, final thrombolysis in myocardial infarction (TIMI) flow and final TIMI myocardial perfusion or blush grade were significantly better with DS in NRSs, and non\u2010significantly better in RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The available evidence suggests that DS in STEMI might be associated with better clinical and procedural outcomes, as compared with SP. However, the fact that RCTs account for the minority of available data and that most of the available studies poorly reflect current clinical practice, as well as the existence of publication bias, preclude drawing definitive conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12190","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T11:39:52Z","timestamp":1429270792000},"page":"119-131","source":"Crossref","is-referenced-by-count":30,"title":["Direct Stenting Versus Pre\u2010Dilation in ST\u2010Elevation Myocardial Infarction: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"LORENZO","family":"AZZALINI","sequence":"first","affiliation":[{"name":"Interventional Cardiology Division Department of Medicine Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XAVIER","family":"MILL\u00c1N","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Division Department of Medicine Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HUNG Q.","family":"LY","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Division Department of Medicine Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHILIPPE L.","family":"L'ALLIER","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Division Department of Medicine Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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