{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:12:58Z","timestamp":1762866778807},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to evaluate the impact of aortic valve (AV) and left ventricle outflow tract (LVOT) calcium on paravalvular regurgitation (PVR) and need for balloon post\u2010dilatation (BPD) during transcatheter aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The overall study population comprised 152 patients. Calcium mass and volume of AV and LVOT were estimated from contrast\u2010enhanced multislice computed tomography imaging, using 3 thresholds for calcium detection [650, 850, and 1,050 Hounsfield units (HU)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A self\u2010expandable prosthesis was implanted in 67.8% of patients and a balloon\u2010expandable prosthesis in the remaining. Eleven patients required BPD and 82 patients presented post\u2010procedural PVR, which was mild in 44.1% and moderate in 9.9%. The greatest discriminatory value for PVR\u2009\u2265\u2009mild was seen for calcium volume using 850 HU threshold, with an area under the curve of 0.72 (95%CI 0.64\u20130.80, P\u2009&lt;\u20090.001) for AV and of 0.63 (95%CI 0.54\u20130.72, P\u2009=\u20090.008) for LVOT. For 850\u2009HU threshold, the calcium volume cut\u2010off with the highest sum of sensitivity and specificity for PVR was 157\u2009mm<jats:sup>3<\/jats:sup> for AV and 0.6\u2009mm<jats:sup>3<\/jats:sup> for LVOT. In multivariate logistic regression analysis, the presence of AV calcium \u2265157\u2009mm<jats:sup>3<\/jats:sup> (OR 3.83, 95%CI 1.81\u20138.10, P\u2009&lt;\u20090.001) and \u2265267\u2009mm<jats:sup>3<\/jats:sup> (OR 11.3, 95%CI 1.2\u2013103.1, P\u2009=\u20090.03) were the only independent predictors of PVR and BPD, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AV calcium volume was an independent predictor of PVR and BPD in patients submitted to TAVI. Our results support a systematic assessment of AV calcium volume to identify patients at increased risk of post\u2010procedural PVR. (J Interven Cardiol 2016;29:117\u2013123)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12267","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T13:16:30Z","timestamp":1451999790000},"page":"117-123","source":"Crossref","is-referenced-by-count":27,"title":["Aortic Valve Calcium Volume Predicts Paravalvular Regurgitation and the Need for Balloon Post\u2010Dilatation After Transcatheter Aortic Valve Implantation"],"prefix":"10.1111","volume":"29","author":[{"given":"Paulo","family":"Fonseca","sequence":"first","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Divino Esp\u00edrito Santo Hospital Ponta Delgada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco Gama","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vila Nova de Gaia Hospital Center Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1039"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.108.827717"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2012.11.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.03.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivu413"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.030"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-013-0197-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu162"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.03.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I6A126"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0870-2551(11)70015-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I5A92"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.05.014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.045"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joic.12267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:55:42Z","timestamp":1695732942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joic.12267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,5]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/joic.12267"],"URL":"https:\/\/doi.org\/10.1111\/joic.12267","archive":["Portico"],"relation":{},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,5]]}}}