{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:01:37Z","timestamp":1761541297708},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>In\u2010stent restenosis (ISR) is a limitation of percutaneous coronary intervention and has been linked to specific clinical and angiographic variables. We aimed to simultaneously assess thrombosis biomarkers and lipid levels in patients with and without ISR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients (n\u2009=\u2009170) with a history of coronary stenting undergoing elective angiography were studied. Blood samples for thrombelastography, light transmittance aggregometry, and lipid levels were obtained prior to cardiac catheterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients (41%) had ISR (&gt;50% luminal diameter stenosis). Among patients with ISR, 40 (58%) had ISR in more than one stent bed. Patients with ISR were more often female (37.7% vs. 21.8%, P\u2009=\u20090.04), had higher thrombin\u2010induced platelet\u2010fibrin clot strength (TIP\u2010FCS) (69.9\u2009mm vs. 65.6\u2009mm, P\u2009&lt;\u20090.001), and a higher ApoB\/A1 ratio (0.65 vs. 0.59, P\u2009=\u20090.03). In patients on dual antiplatelet therapy (n\u2009=\u200986), there were no differences in ADP\u2010, arachidonic acid\u2010, and collagen\u2010induced platelet aggregation between groups. The frequency of patients with ISR increased with TIP\u2010FCS quartiles and by ROC analysis, TIP\u2010FCS\u2009=\u200967.0\u2009mm was the cutpoint for identification of ISR (AUC\u2009=\u20090.80 (95%CI 0.73\u20130.87, P\u2009&lt;\u20090.0001). By multivariate analysis, TIP\u2010FCS \u226567.0\u2009mm strongly associated with ISR (OR\u2009=\u20097.3, P\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with ISR identified at the time of cardiac catheterization have a prothrombotic phenotype indicated by high TIP\u2010FCS, a novel marker. Studies to confirm the prognostic utility of high TIP\u2010FCS for the development of ISR are ongoing. (J Interven Cardiol 2016;29:168\u2013178)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12277","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T08:08:32Z","timestamp":1454054912000},"page":"168-178","source":"Crossref","is-referenced-by-count":14,"title":["Thrombin\u2010Induced Platelet\u2010Fibrin Clot Strength Identified by Thrombelastography"],"prefix":"10.1111","volume":"29","author":[{"given":"Kevin P.","family":"Bliden","sequence":"first","affiliation":[{"name":"Sinai Center for Thrombosis Research Sinai Hospital Baltimore Maryland"},{"name":"Inova Heart and Vascular Institute Inova Medical Center Fairfax Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya S.","family":"Tantry","sequence":"additional","affiliation":[{"name":"Sinai Center for Thrombosis Research Sinai Hospital Baltimore Maryland"},{"name":"Inova Heart and Vascular Institute Inova Medical Center Fairfax 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