{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:18:43Z","timestamp":1696231123797},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Peri\u2010stent contrast staining (PSS) after sirolimus\u2010eluting stent implantation is associated with target lesion revascularization (TLR) and very late stent thrombosis. However, the risk factors and clinical sequelae of PSS after second\u2010generation DES implantation remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This study comprised 2,090 patients with 2,883 lesions treated with second\u2010generation DES from April 2009 to February 2013. Angiographic findings and clinical outcomes were compared between PSS and non\u2010PSS groups. Follow\u2010up angiography was available for 2,411 lesions. PSS was observed in 23 lesions: 4 in biolimus\u2010eluting stents, 4 in zotarolimus\u2010eluting stents (ZES), and 15 in everolimus\u2010eluting stents (EES). Right coronary artery lesions, chronic total occlusion (CTO), and lesions with severe angulation (&gt;90\u00b0) were more frequent in the PSS group compared with the non\u2010PSS group. Lesions were longer and the cumulative TLR incidence at 3 years was higher in the PSS group than those in the non\u2010PSS group (27.9\u2009mm vs. 19.4\u2009mm, P\u2009&lt;\u20090.0001; 27.4% vs. 8.6%, P\u2009=\u20090.0002). There was no significant difference in stent thrombosis between the two groups. Multivariable analysis identified CTO [odds ratio (OR) 3.75, 95%CI 1.52\u20138.88, P\u2009=\u20090.005] as an independent predictor of PSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSS after second\u2010generation DES implantation was associated with an increased risk of subsequent TLR. CTO was the independent predictor of PSS. (J Interven Cardiol 2016;29:179\u2013187)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12282","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T08:04:42Z","timestamp":1454054682000},"page":"179-187","source":"Crossref","is-referenced-by-count":4,"title":["Risk Factors and Clinical Impacts of Peri\u2010Stent Contrast Staining After Second\u2010Generation Drug\u2010Eluting Stent Implantation"],"prefix":"10.1111","volume":"29","author":[{"given":"Takahiro","family":"Tokuda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Saiseikai Yokohama City Eastern Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Saiseikai Yokohama City Eastern Hospital Yokohama Kanagawa 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