{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:09:12Z","timestamp":1770908952865,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2015R1A2A2A01002731"],"award-info":[{"award-number":["2015R1A2A2A01002731"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the long\u2010term clinical outcomes of biolimus\u2010eluting stents with biodegradable polymers in real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term clinical outcomes of biolimus\u2010eluting stents have not been clearly established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 824 all\u2010comer patients (971 lesions) treated with unrestricted implantation of a biolimus\u2010eluting stent with a biodegradable polymer were prospectively enrolled. Patients were divided into complex (413 patients) versus noncomplex (411 patients) groups according to the complexity of coronary lesions. Long\u2010term clinical outcomes for stent efficacy (target lesion revascularization) and safety (composite of cardiac death, target lesion\u2010related myocardial infarction, and definite or probable stent thrombosis) were compared between the two groups during 5 years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complex group showed higher rates of decreased left ventricular ejection fraction, impaired renal function, previous history of myocardial infarction, and diabetes mellitus compared to the noncomplex group. In the overall population, the 5\u2010year cumulative rate of target lesion revascularization was 4.8% (8.3% in the complex group vs 1.6% in the noncomplex group, P\u2009&lt;\u20090.001). For stent safety, the 5\u2010year cumulative rate for a composite of cardiac death, target lesion\u2010related myocardial infarction, and stent thrombosis was 2.5% overall (3.9% in the complex group vs 1.1% in the noncomplex group, P\u2009=\u20090.010). Overall 5\u2010year cumulative rate of stent thrombosis was 0.4% (0.5% in the complex vs 0.2% in the noncomplex group, P\u2009=\u20090.561) with no very late stent thrombosis (VLST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biodegradable polymer\u2010based biolimus\u2010eluting stents showed favorable efficacy and safety in all\u2010comer patients during 5 years of follow\u2010up. (J Interven Cardiol 2016;29:162\u2013167)<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12283","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T12:40:59Z","timestamp":1456836059000},"page":"162-167","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Clinical Outcomes of a Biodegradable Polymer\u2010Based Biolimus\u2010Eluting Stent"],"prefix":"10.1111","volume":"29","author":[{"given":"Eui","family":"Im","sequence":"first","affiliation":[{"name":"Yongin Severance Hospital Yonsei University Health System Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwang\u2010Sil","family":"Kim","sequence":"additional","affiliation":[{"name":"Yongin Severance Hospital Yonsei University Health System Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong\u2010Keuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Guk","family":"Ko","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong\u2010Ki","family":"Hong","sequence":"additional","affiliation":[{"name":"Severance Cardiovascular Hospital Yonsei University Health System Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61444-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.6.1533"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067193"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.13"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61672-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61962-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61852-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.045"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.019"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ba622"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A17"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M12_13"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.09.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304273"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12283","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joic.12283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T18:47:16Z","timestamp":1696186036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joic.12283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/joic.12283"],"URL":"https:\/\/doi.org\/10.1111\/joic.12283","archive":["Portico"],"relation":{},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}