{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:58Z","timestamp":1787015578678,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated the safety and efficacy of orbital atherectomy in real\u2010world patients with severe coronary artery calcification (CAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The presence of severe CAC increases the complexity of percutaneous coronary intervention as it may impede stent delivery and optimal stent expansion. Atherectomy may be an indispensable tool for uncrossable or undilatable lesions by modifying severe CAC. Although the ORBIT I and II trials report that orbital atherectomy was safe and effective for the treatment of severe CAC, patients with kidney disease, recent myocardial infarction, long diffuse disease, severe left ventricular dysfunction, and unprotected left main disease were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 458 consecutive patients with severe CAC who underwent orbital atherectomy followed by stenting from October 2013 to December 2015 at 3 centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary endpoint of major adverse cardiac and cerebrovascular events at 30\u2009days was 1.7%. Low rates of 30\u2010day all\u2010cause mortality (1.3%), myocardial infarction (1.1%), target vessel revascularization (0%), stroke (0.2%), and stent thrombosis (0.9%) were observed. Angiographic complications were low: perforation was 0.7%, dissection 0.9%, and no\u2010reflow 0.7%. Emergency coronary artery bypass graft surgery was performed in 0.2% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the largest real\u2010world study of patients who underwent orbital atherectomy, including high\u2010risk patients who were not surgical candidates as well as those with very complex coronary anatomy, acute and short\u2010term adverse clinical event rates were low. A randomized clinical trial is needed to identify the ideal treatment strategy for patients with severe CAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joic.12310","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T03:42:47Z","timestamp":1467258167000},"page":"357-362","source":"Crossref","is-referenced-by-count":50,"title":["Real\u2010World Multicenter Registry of Patients with Severe Coronary Artery Calcification Undergoing Orbital Atherectomy"],"prefix":"10.1111","volume":"29","author":[{"given":"Michael S.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Interventional Cardiology UCLA Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Northwell Health Manhasset New 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