{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:58:21Z","timestamp":1790668701490,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine predictors for long\u2010term outcome in high\u2010risk patients undergoing transcatheter edge\u2010to\u2010edge mitral valve repair (TMVR) for severe mitral regurgitation (MR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no data on predictors of long\u2010term outcome in high\u2010risk real\u2010world patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From August 2009 to April 2011, 126 high\u2010risk patients deemed inoperable were treated with TMVR in two high\u2010volume university centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MR could be successfully reduced to grade \u22642 in 92.1% of patients (116\/126 patients). Long\u2010term clinical follow\u2010up up to 5 years (95.2% follow\u2010up rate) revealed a mortality rate of 35.7% (45\/126 patients). Repeat mitral valve treatment (surgery or intervention) was needed in 19 patients (15.1%). Long\u2010term clinical improvement was demonstrated with 69% of patients being in NYHA class \u2264II. In a multivariable Cox regression analysis, the post\u2010procedural grade of MR (hazard ratio [HR] 1.55 per grade, <jats:italic>P<\/jats:italic>\u2009=\u20090.035), the left ventricular ejection fraction (HR 0.58 for difference between 75th and 25th percentile, <jats:italic>P<\/jats:italic>\u2009=\u20090.031) and the glomerular filtration rate (HR 0.33 for 75th vs 25th percentile, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) were independent predictors for long\u2010term mortality. Patients with primary MR and a post\u2010procedural MR grade \u22641 had the most favorable long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study determines predictors of long\u2010term clinical outcome after TMVR and demonstrates that the grade of residual MR determines long\u2010term survival. Our data suggest that it might be of benefit reducing residual MR to the lowest possible MR grade using TMVR\u2014especially in selected high\u2010risk patients with primary MR who are not considered as candidates for surgical MVR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12376","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T03:23:23Z","timestamp":1490757803000},"page":"226-233","source":"Crossref","is-referenced-by-count":58,"title":["Predictors for long\u2010term survival after transcatheter edge\u2010to\u2010edge mitral valve repair"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-8808","authenticated-orcid":false,"given":"Mathias","family":"Orban","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich 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