{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:07:45Z","timestamp":1769155665368,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001502","name":"Blue Cross Blue Shield of Michigan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence, risk factors, and outcomes associated with Contrast\u2010induced nephropathy (CIN) after Percutaneous Vascular Intervention (PVI) in contemporary medical practice are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 13\u2009126 patients undergoing PVI were included in the analysis. CIN was defined as an increase in serum creatinine from pre\u2010PVI baseline to post\u2010PVI peak Cr of \u22650.5\u2009mg\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CIN occurred in 3% (400 patients) of the cohort, and 26 patients (6.5%) required dialysis. Independent predictors of CIN were high and low body weight, diabetes, heart failure, anemia, baseline renal dysfunction, critical limb ischemia, and a higher acuity of the PVI procedure and a contrast dose that was greater than three times the calculated creatinine clearance (CCC) (adjusted OR 1.4, 95% CI: 1.1\u20101.8, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). CIN was strongly associated with adverse outcome including in\u2010hospital death (adjusted OR 18.1, CI 10.7\u201030.6, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), myocardial infarction (adjusted OR 16.2, CI 8.9\u201029.5, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), transient ischemic attack\/stroke (adjusted OR 5.5, CI 3.2\u201014.9, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), vascular access complications (adjusted OR 3.4, CI 2.3\u20105, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and transfusion (adjusted OR 7, CI 5.4\u20109, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Hospital stay was longer in patients who developed CIN versus those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CIN is not an uncommon complication associated with PVI, can be reliably predicted from pre\u2010procedural variables, including a contrast dose of greater than three times the CCC and is strongly associated with the risk of in\u2010hospital death, MI, stroke, transfusion, and increased hospital length of stay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12379","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T07:07:41Z","timestamp":1491376061000},"page":"274-280","source":"Crossref","is-referenced-by-count":45,"title":["Contrast\u2010induced nephropathy in patients undergoing endovascular peripheral vascular intervention: Incidence, risk factors, and outcomes as observed in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-0344","authenticated-orcid":false,"given":"P. Michael","family":"Grossman","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Michigan School of Medicine Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Michigan School of Medicine Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert D.","family":"Aronow","sequence":"additional","affiliation":[{"name":"Michigan Heart Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Boros","sequence":"additional","affiliation":[{"name":"Munson Medical Center Traverse City Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Nypaver","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery Henry Ford Health System Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore L.","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Detroit Medical Center Cardiovascular Institute Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.","family":"Henke","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery University of Michigan School of Medicine Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-0218","authenticated-orcid":false,"given":"Hitinder S.","family":"Gurm","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Michigan School of Medicine Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-4-501"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595090"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016043.87291.33"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20316"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390180067011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90437-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1093"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001887"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02771-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.023"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.05.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.910638"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957381"},{"key":"e_1_2_9_17_1","first-page":"81","article-title":"Renal dysfunction after angiography; a risk factor analysis in patients with peripheral vascular disease","volume":"32","author":"Gussenhoven MJ","year":"1991","journal-title":"J Cardiovasc Surg"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00150-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901193200303"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.068"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67131.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-009-0052-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.11.011"},{"key":"e_1_2_9_25_1","first-page":"467","article-title":"The relative renal safety of iodixanol and low\u2010osmolar contrast media in patients undergoing percutaneous coronary intervention. 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