{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:56Z","timestamp":1740137156208,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001502","name":"Blue Cross Blue Shield of Michigan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the patterns of use and outcomes associated with eptifibatide and abciximab administration among dialysis patients who underwent percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Contraindicated medications are frequently administered to dialysis patients undergoing PCI often resulting in adverse outcomes. Eptifibatide is a glycoprotein IIb\/IIIa inhibitor that is often used during PCI and is contraindicated in dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included dialysis patients who underwent PCI from January 2010 to September 2015 at 47 hospitals in Michigan. We compared outcomes between patients who received eptifibatide compared with abciximab. Both groups required concurrent treatment with unfractionated heparin only. In\u2010hospital outcomes included repeat PCI, bleeding, major bleeding, need for transfusion, and death. Optimal full matching was used to adjust for non\u2010random drug administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 177\u2009963 patients who underwent PCI, 4303 (2.4%) were on dialysis. Among those, 384 (8.9%) received eptifibatide and 100 (2.3%) received abciximab. Prior to matching, patients who received eptifibatide had higher pre\u2010procedural hemoglobin levels (11.3\u2009g\/dL vs. 10.7\u2009g\/dL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and less frequently had a history of myocardial infarction (36.5% vs. 52.0%; <jats:italic>P<\/jats:italic>\u2009=\u20090.005). After matching, there were no significant differences in in\u2010hospital outcomes between eptifibatide and abciximab including transfusion (aOR: 1.15; 95%CI: 0.55\u20102.40; <jats:italic>P<\/jats:italic>\u2009=\u20090.70), bleeding (1.47; 0.64\u20103.40; <jats:italic>P<\/jats:italic>\u2009=\u20090.36), major bleeding (4.68; 0.42\u201052.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.21), repeat PCI (0.38; 0.03\u20104.23; <jats:italic>P<\/jats:italic>\u2009=\u20090.43), and death (1.53; 0.2\u20109.05; <jats:italic>P<\/jats:italic>\u2009=\u20090.64).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite being contraindicated in dialysis, eptifibatide was used approximately 3.5 times more frequently than abciximab among dialysis patients undergoing PCI but was associated with similar in\u2010hospital outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12388","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T23:10:11Z","timestamp":1495581011000},"page":"291-300","source":"Crossref","is-referenced-by-count":1,"title":["The comparative safety of abciximab versus eptifibatide in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2)"],"prefix":"10.1111","volume":"30","author":[{"given":"Devraj","family":"Sukul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Detroit Medical Center\u2010Cardiovascular Institute Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Hanzel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine William Beaumont Hospital, Heart and Vascular Royal Oak Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Division of Cardiology Henry Ford Health System Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Cannon","sequence":"additional","affiliation":[{"name":"McLaren\u2010Northern Michigan Regional Hospital Petoskey Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine St. John Hospital and Medical Center Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-0218","authenticated-orcid":false,"given":"Hitinder S.","family":"Gurm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan"},{"name":"Cardiovascular Medicine VA Ann Arbor Healthcare System Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart Disease and Stroke Statistics\u20102016 Update: a report from the American Heart Association","author":"Mozaffarian D","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.084996"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00179.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.05.018"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01745-X"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2003.16048.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.11.1377"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1800"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002043"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.08.020"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10172-0"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03400-0"},{"key":"e_1_2_13_15_1","unstructured":"Integrilin(R) (eptifibatide). Full prescribing information. Available at:https:\/\/www.merck.com\/product\/usa\/pi_circulars\/i\/integrilin\/integrilin_pi.pdf. Accessed: August 13 2016."},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2002.tb01072.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.541995"},{"key":"e_1_2_13_18_1","unstructured":"NCDR CathPCI Registry v4.4 Coder's Data Dictionary. Available at:https:\/\/www.ncdr.com\/WebNCDR\/docs\/public-data-collection-documents\/cathpci_v4_codersdictionary_4-4.pdf. Accessed: July 28 2016."},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.007"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1198\/106186006X137047"},{"key":"e_1_2_13_21_1","unstructured":"R Development Core Team. R: a language and environment for statistical computing. 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