{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:27:29Z","timestamp":1761514049519,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["Cell Therapy Program: Translational Platform"],"award-info":[{"award-number":["Cell Therapy Program: Translational Platform"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intramyocardial injection of bone marrow cells (BMC) in refractory angina patients with chronic myocardial ischemia has shown to be safe and improve clinical status during short\u2010term follow\u2010up. However, scarce data are available on long\u2010term (&gt;12 months) safety and efficacy. Therefore, the occurrence of clinical events and the long\u2010term clinical effects of intramyocardial BMC injection were evaluated in patients with chronic myocardial ischemia up to 10 years after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic>\u2009=\u2009100, age 64\u2009\u00b1\u20099 years, male 88%) with chronic myocardial ischemia who underwent intramyocardial BMC injection between 2004 and 2010 were evaluated. During yearly outpatient clinic visits, the occurrence of clinical events was documented. In addition, clinical status was assessed according to the Canadian Cardiovascular Society (CCS) score and quality of life was measured using the Seattle Angina Questionnaire. These parameters were evaluated at baseline and during the first year, followed by cross\u2010sectional long\u2010term follow\u2010up which was performed in 2011 and 2014. No adverse events considered related to the procedure occurred during 10 years of follow\u2010up. Observed annual mortality rate and annual myocardial infarction rate were 3.8% and 1.9% per year, respectively. When compared to baseline, CCS class and quality of life remained significantly better during 5\u2010year follow\u2010up after BMC treatment (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present long\u2010term follow\u2010up study shows that intramyocardial BMC injection in patients with chronic myocardial ischemia is safe and improves both angina complaints and quality of life up to 5 years after BMC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12408","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:44:58Z","timestamp":1501231498000},"page":"440-447","source":"Crossref","is-referenced-by-count":6,"title":["Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long\u2010term results"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6284-6480","authenticated-orcid":false,"given":"Sander F.","family":"Rodrigo","sequence":"first","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"van Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia L.","family":"Beeres","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Center Leiden The Netherlands"},{"name":"Jon J. van Rood Center for Clinical Transfusion Research, Sanquin Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem E.","family":"Fibbe","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin 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