{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:50:22Z","timestamp":1769608222779,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to compare the efficacy and safety of prasugrel and ticagrelor in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence from randomized head\u2010to\u2010head comparison between prasugrel and ticagrelor is rare regarding clinical endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, the Cochrane Library, and Web of Science were queried with the terms \u201cprasugrel,\u201d \u201cticagrelor,\u201d and \u201crandomized.\u201d Relevant randomized controlled trials (RCTs) or the same terms were also surveyed using <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/escardio.org\">escardio.org<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/pcronline.org\">pcronline.org<\/jats:ext-link>, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/tctmd.com\">tctmd.com<\/jats:ext-link>. The clinical endpoints were death, myocardial infarction (MI), stroke, and stent thrombosis (ST) for efficacy, and any bleeding for safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total number of 2068 patients in 12 RCTs, whose longest follow\u2010up period was 6 months, was included in this study. The risks of death (odds ratio [OR]: 0.86, 95% confidence interval [CI]: 0.46\u20101.62, <jats:italic>P<\/jats:italic>\u2009=\u20090.647), MI (OR: 1.61, 95%CI: 0.71\u20103.62, <jats:italic>P<\/jats:italic>\u2009=\u20090.252), stroke (OR: 1.45, 95%CI: 0.25\u20108.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.680), and ST (OR: 0.76, 95%CI: 0.20\u20102.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.677) were similar between prasugrel and ticagrelor, respectively. While the incidence of bleeding according to the Bleeding Academic Research Consortium definitions was also comparable (OR: 0.83, 95%CI: 0.45\u20101.52, <jats:italic>P<\/jats:italic>\u2009=\u20090.539), that according to the Thrombolysis in Myocardial Infarction criteria was lower in prasugrel than ticagrelor (OR: 0.49, 95%CI: 0.24\u20100.97, <jats:italic>P<\/jats:italic>\u2009=\u20090.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the efficacy was similar between prasugrel and ticagrelor, prasugrel may be associated with a lower risk of bleeding compared with ticagrelor during short\u2010 to mid\u2010term follow\u2010up period after PCI. Further studies are warranted in a larger patient population during longer\u2010term follow up to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12416","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T04:52:35Z","timestamp":1502686355000},"page":"457-464","source":"Crossref","is-referenced-by-count":7,"title":["Head\u2010to\u2010head comparison of prasugrel versus ticagrelor in patients undergoing percutaneous coronary intervention: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-5459","authenticated-orcid":false,"given":"Ryota","family":"Sakurai","sequence":"first","affiliation":[{"name":"Department of Cardiac Rehabilitation School of Medicine International University of Health and Welfare Chiba 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