{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:25:47Z","timestamp":1777116347463,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI16C2319"],"award-info":[{"award-number":["HI16C2319"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was sought to evaluate the effectiveness of patent foramen ovale (PFO) closure in selected patients (PFO shunt grade more than moderate) with cryptogenic stroke (CS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether closure of PFO is an effective treatment for prevention of CS is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive 158 patients (mean age: 49.9 years old, closure group: 67 patients, medication group: 91 patients) were enrolled. The primary end point was a composite of recurrent stroke and transient ischemic attack.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were similar between the two groups, except age which was younger in the closure group (47.7\u2009\u00b1\u200910.8 vs 51.9\u2009\u00b1\u20099.9, <jats:italic>P<\/jats:italic>\u2009=\u20090.013), and the presence of shunt at rest was more common in the closure group (35.8% vs 10.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). Procedural success was 94.0%. Over a mean follow\u2010up of 27.8 months, a total of six primary end point, all of which were strokes, occurred only in the medication group (6.6% vs 0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.039). Stroke\u2010free survival rate was significantly higher in the closure group (<jats:italic>P<\/jats:italic>\u2009=\u20090.026)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that PFO closure may be an effective treatment strategy to prevent recurrent stroke or TIA for patients with CS if it is conducted in selective patients who have PFO shunt more than moderate grade.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12430","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T03:26:43Z","timestamp":1503372403000},"page":"368-374","source":"Crossref","is-referenced-by-count":10,"title":["Effect of patent foramen ovale closure for prevention on recurrent stroke or transient ischemic attack in selected patients with cryptogenic stroke"],"prefix":"10.1111","volume":"31","author":[{"given":"Minsu","family":"Kim","sequence":"first","affiliation":[{"name":"Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiology New Korea Hostipital, Gimpo\u2010si Gyeongggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeonggeun","family":"Moon","sequence":"additional","affiliation":[{"name":"Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"},{"name":"Gachon Cardiovascular Research Institute Gachon University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pyung Chun","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"},{"name":"Gachon Cardiovascular Research Institute Gachon University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yae Min","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"},{"name":"Gachon Cardiovascular Research Institute Gachon University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong\u2010Bae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Young","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Radiology Gachon University Gil Medical Center Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-7178","authenticated-orcid":false,"given":"Woong Chol","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiology Gachon University Gil Medical Center Incheon Republic of Korea"},{"name":"Gachon Cardiovascular Research Institute Gachon University Incheon Republic of 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