{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:24:35Z","timestamp":1791224675714,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is progressive interest worldwide in spontaneous coronary artery dissection (SCAD). To identify a SCAD cohort and compare risk factors, presentation, and management outcomes compared to acute coronary syndrome (ACS) matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis was performed from 2000 to 2015. Clinical data included a neuropsychiatric history, with management and clinical outcomes assessed at 12 months. Patients were matched on a 1:3 case\u2010control basis according to type of ACS. Twenty\u2010two SCAD patients were matched to 66 controls by ACS type (ST\u2010elevation myocardial infarction 45%, Non\u2010ST\u2010elevation myocardial infarction 41%, unstable angina 14%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SCAD group were more likely female (77.3% vs 19.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), of younger age (48.7\u2009\u00b1\u200910.7 years vs 61.3\u2009\u00b1\u200910.6 years, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) with no cases of diabetes (0% vs 33.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), compared to controls. SCAD patients had a high prevalence of anxiety, depression or previous neuropsychiatric history (52.4% SCAD vs 1.5% ACS, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). A conservative revascularization strategy with stenting was performed in a minority of SCAD patients (13.6% SCAD vs 83.3% ACS, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), with no significant difference in cumulative major adverse cardiac or cerebrovascular events (MACCE) of death, stroke, re\u2010admission, or repeat angiography rates between both groups (13.6% SCAD vs 27.3% ACS <jats:italic>P<\/jats:italic>\u2009=\u2009NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCAD affects young females with a paucity of cardiovascular risk factors. The major risk factor for SCAD was a history of anxiety, depression, or neuropsychiatric illness. A conservative approach to SCAD revascularization led to similar MACCE when compared to ACS controls undergoing guideline revascularization at 12 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12447","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T01:12:39Z","timestamp":1505956359000},"page":"41-47","source":"Crossref","is-referenced-by-count":22,"title":["Different patients, different outcomes: A case\u2010control study of spontaneous coronary artery dissection versus acute coronary syndrome"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-6884","authenticated-orcid":false,"given":"Heath","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital Melbourne Fitzroy Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Paratz","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's 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