{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:05:14Z","timestamp":1762607114412,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to assess feasibility and clinical effectiveness of the MitraClip device in octogenarians suffering from severe mitral valve regurgitation due to chordae rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The MitraClip procedure is a suitable technique in high\u2010risk surgical patients to achieve safe and effective percutaneous repair of mitral valve regurgitation. Octogenarians show cumulative risk and social aspects hindering mitral valve surgery. No data exists regarding the use of the MitraClip device in high\u2010risk octogenarians suffering from mitral valve chordae rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between October 2009 and March 2017 98 high\u2010risk octogenarians (society of thoracic surgeons score [STS]: 9.7%\u2009\u00b1\u20090.8) with mitral valve prolapse and consecutively chordae rupture were treated with the MitraClip after interdisciplinary discussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Successful mitral valve repair was achieved in 91% of the octogenarians. Repair of the mitral valve caused immediate and significant reduction of dyspnoea (NYHA class: 3.5\u2009\u00b1\u20090.4 vs 2.0\u2009\u00b1\u20090.3; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001), cardiac reverse remodeling (LVESD: 39\u2009\u00b1\u20090.8 vs 35\u2009\u00b1\u20090.8; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01) and amelioration of cardiac biomarkers (NTproBNP (4884\u2009\u00b1\u200952\u2009\u2009ng\/L vs 2473\u2009\u00b1\u2009210\u2009ng\/L; <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.05,). Effects were stable over the 12 months observation period. None of our patients died intraprocedurally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Percutaneous repair of chordae rupture is feasible and safe in high\u2010risk octogenarians. The MitraClip should be considered to repair severe mitral valve regurgitation due to mitral valve chordae rupture in high\u2010risk octogenarians after interdisciplinary discussion even facing a challenging anatomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12455","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:12:38Z","timestamp":1507853558000},"page":"76-82","source":"Crossref","is-referenced-by-count":8,"title":["Percutaneous repair of severe mitral valve regurgitation secondary to chordae rupture in octogenarians using MitraClip"],"prefix":"10.1111","volume":"31","author":[{"given":"Nicolas","family":"Geis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Raake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derliz","family":"Mereles","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Chorianopoulos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffi","family":"Bekeredjian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-5502","authenticated-orcid":false,"given":"Sven T.","family":"Pleger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Cardiology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1136\/hrt.30.2.203","article-title":"Late murmurs and non\u2010ejection (\u201cmid\u2010late\u201d) systolic clicks. 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