{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:36:57Z","timestamp":1791815817471,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing transcatheter aortic valve replacement (TAVR) are often characterized by risk factors not reflected in conventional risk scores. In this context, little is known about the outcome of patients suffering from an active cancer disease (ACD). The objective was to determine the prevalence, clinical characteristics, perioperative outcomes, and mortality of patients with ACD undergoing TAVR compared to those with a history of cancer (HCD) and controls without known tumor disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TAVR patients between 02\/2006 and 09\/2014 were stratified according to the presence of ACD, HCD, and control. All\u2010cause\u2010mortality at 1\u2010year was the primary end point. All end point definitions were subject to the Valve Academic Research Consortium II definitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1821 patients were included: 99 patients (5.4%) suffered from ACD and 251 patients (13.8%) had HCD. ACD was related to a solid organ or hematological source in 72.7% and 27.3%, respectively. Patients with ACD were more often male (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) and had a lower logisticEuroScore I (<jats:italic>P<\/jats:italic>\u2009=\u20090.033). Overall rates of VARC\u2010II defined periprocedural myocardial infarction, stroke, bleeding, access\u2010site complications, and acute kidney injury were not different between groups. Thirty\u2010day mortality did not differ between patients with ACD, HCD, and controls (6.1% vs 4.4% vs 7.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.176). All\u2010cause 1\u2010year mortality was higher in patients with ACD compared HCD and controls (37.4% vs 16.4% vs 20.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). ACD was an independent predictor of all\u2010cause 1\u2010year mortality (HR 2.10, 95%\u2010CI 1.41\u20103.13, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of ACD in patients undergoing TAVR is associated with significantly higher 1\u2010year mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12458","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:42:43Z","timestamp":1511397763000},"page":"188-196","source":"Crossref","is-referenced-by-count":57,"title":["Impact of active cancer disease on the outcome of patients undergoing transcatheter aortic valve replacement"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-7923","authenticated-orcid":false,"given":"Norman","family":"Mangner","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig\u2010University Hospital Leipzig 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