{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:10:27Z","timestamp":1757700627363,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the 9\u2010month safety and efficacy of polymer\u2010free sirolimus eluting drug eluting stents in septuagenarians and octogenarians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An all\u2010comer, worldwide single armed trial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier NCT02629575) was conducted to demonstrate the safety and efficacy of an ultra\u2010thin strut, polymer\u2010free sirolimus eluting stent (PF\u2010SES). The primary endpoint was the 9\u2010month target revascularization rate (TLR). Secondary endpoints included the rates of major adverse cardiac events (MACE), stent thrombosis (ST) and bleeding (BARC) in septuagenarians (\u226570 years, &lt;80 years), and in octogenarians (\u226580 years) to be compared to the younger patient group (&lt;70 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1607 patients were treated with PF\u2010SES in the sub\u201070\u2010year\u2010old age group, 694 in septuagenarians, and 371 in the octogenarian patient group. At 9 months, the MACE rates were 7.2% in octogenarians, 5.3% in septuagenarians, and 3.0% in the younger patient group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). These were mostly driven by all\u2010cause mortality (4.4% vs 1.9% vs 0.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) while the TLR rates were only numerically lower in the younger age group (<jats:italic>P<\/jats:italic>\u2009=\u20090.080). BARC 1\u20105 bleeding events were more frequent in the older age group (1.9% vs 2.7% vs 4.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.012) whereas the rates for ST were not different (0.7% vs 0.6% vs 0.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.970).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In octogenarians treated with PF\u2010SES, the rates for MACE, overall mortality, and bleeding are higher as compared to the younger age groups. However, the rates for TLR and ST were not significantly different across the investigated age groups. PF\u2010SES are safe and effective in octogenarians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12472","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T11:42:34Z","timestamp":1512474154000},"page":"338-344","source":"Crossref","is-referenced-by-count":2,"title":["9\u2010month results of polymer\u2010free sirolimus eluting stents in young patients compared to a septuagenarian and octogenarian all\u2010comer population"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-6646","authenticated-orcid":false,"given":"Behrouz","family":"Kherad","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Campus Virchow Klinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-4505","authenticated-orcid":false,"given":"Matthias","family":"Waliszewski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Campus Virchow Klinikum"},{"name":"Medical Scientific Affairs B.Braun Melsungen AG Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Leschke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie Angiologie und Pneumologie Klinikum Esslingen Esslingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Ali","family":"Kader","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Pulau Pinang Penang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liew Houng","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Queen Elizabeth II Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Lozano","family":"Ruiz\u2010Poveda","sequence":"additional","affiliation":[{"name":"Servicio de Hemodin\u00e1mica y Cardiolog\u00eda Intervencionista Hospital General Universitario de Ciudad Real Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Campus Virchow Klinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Krackhardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Campus Virchow Klinikum"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Census Bureau https:\/\/www.census.gov\/population\/projections\/data\/national\/2014\/summarytables.html accessed March 31 2017."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16-083"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.031"},{"key":"e_1_2_8_5_1","first-page":"78","article-title":"Are very elderly patients the same compared to the young elderly when acute coronary syndrome","volume":"5","author":"Ramirez Guijarro C","year":"2016","journal-title":"Eur Heart J"},{"key":"e_1_2_8_6_1","article-title":"ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the European society of cardiology (ESC) and of the European association for cardio\u2010thoracic surgery (EACTS)","author":"Valgimigli M","year":"2017","journal-title":"Eur Heart J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026732"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12933-016-0429-y","article-title":"Intracoronary stenting and angiographic results: test efficacy of sirolimus\u2010 and probucol\u2010 and zotarolimus\u2010eluting stents (ISAR\u2010TEST 5) investigators. 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