{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:35:46Z","timestamp":1770842146320,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:00:00Z","timestamp":1514160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to assess indications, procedural success, complications, echocardiographic, and clinical outcomes of percutaneous pulmonary valve implantation (PPVI) in adult patients with congenital heart disease (CHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PPVI offers a non\u2010surgical treatment option for failing prosthetic conduits in pulmonary position. However, efficacy and clinical outcomes after PPVI are still underreported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2008 to March 2016, 25 adult CHD patients with right ventricular outflow tract (RVOT) stenosis and\/or pulmonary regurgitation underwent PPVI in our institution. Clinical and echocardiographic data was collected at baseline, at 12 months of follow\u2010up and yearly afterwards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tetralogy of Fallot and repaired pulmonary atresia were among the most prevalent underlying congenital defects. Twenty\u2010one (84%) received a Medtronic Melody\u00ae and four (16%) patients an Edwards Sapien valve prosthesis. The PPVI procedure was successful in all 25 patients. Pre\u2010stenting was performed in all but two (8%) patients. PPVI reduced peak\u2010to\u2010peak pulmonary valve gradient from 43 (IQR 28\u201060) mmHg to 16 (IQR 14\u201022) mmHg (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Periprocedural complications occurred in two (8%) patients (tricuspid valve damage, pulmonary artery perforation). Over a median follow\u2010up of 43 (IQR 18\u201058) months all patients were alive. Only two (8%) required re\u2010operation and two (8%) developed stent fractures (one of them had not undergone pre\u2010stenting). NYHA functional class improved significantly, with 20 (80%) patients in NYHA class I on follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PPVI with Medtronic Melody or Edwards Sapien valve conduits is safe and provides effective relief from right ventricular outflow tract obstruction or pulmonary regurgitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12477","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T02:36:43Z","timestamp":1514255803000},"page":"251-260","source":"Crossref","is-referenced-by-count":7,"title":["Percutaneous pulmonary valve implantation in grown\u2010up congenital heart disease patients: Insights from the Zurich experience"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-3199","authenticated-orcid":false,"given":"Luca","family":"Oechslin","sequence":"first","affiliation":[{"name":"University Heart Center Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Corti","sequence":"additional","affiliation":[{"name":"University Heart Center Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Greutmann","sequence":"additional","affiliation":[{"name":"University Heart Center Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kretschmar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University Children's Hospital Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Gaemperli","sequence":"additional","affiliation":[{"name":"University Heart Center Zurich 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