{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:04:13Z","timestamp":1793329453802,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to test a novel stent\u2010less revascularization strategy using a combination of excimer laser coronary angioplasty (ELCA) and drug\u2010coated balloon (DCB) for patients with acute coronary syndrome (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous coronary intervention with drug eluting stents is a standard invasive treatment for ACS. Some unsolved issues however remain, such as stent thrombosis and bleeding risks associated with dual antiplatelet therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive ACS patients were planned to receive either a DCB application following ELCA without a stent implantation or conventional revascularization with a coronary stent. The endpoints were (i) major cardiac adverse events (MACEs), defined as the composite of cardiac death, myocardial infarctions, and target lesion revascularization; (ii) target vessel revascularization (TVR); and (iii) angiographic outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since a greater than expected number of patients allocated to the stent\u2010less treatment arm eventually received a bailout stenting, the following 3 as\u2010treated groups were compared; DCB with ELCA group (<jats:italic>N<\/jats:italic>\u2009=\u200960), Stent with ELCA group (<jats:italic>N<\/jats:italic>\u2009=\u200923), and Stent without ELCA group (<jats:italic>N<\/jats:italic>\u2009=\u200985). During a mean follow\u2010up period of 420\u2009\u00b1\u2009137 days, and with angiographic 6\u2010 and 12\u2010month\u2010follow\u2010up rates of 96.7%, 87%, and 81.2%, and 50%, 65.2%, and 45.9%, respectively, the MACE rate did not differ across the groups (10%, 4.3%, and 3.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.22) while an incidence of TVR was more common (15%, 0, and 4.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and the diameter stenosis at 6\u2010months of follow\u2010up was greater (25.7\u2009\u00b1\u200918.2, 14.9\u2009\u00b1\u200913.1 and 16.2\u2009\u00b1\u200915.4%; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) in the DCB with ELCA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The stent\u2010less revascularization strategy with DCB and ELCA was associated with a higher occurrence of restenosis in ACS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12495","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:04:18Z","timestamp":1519243458000},"page":"284-292","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010life experience of a stent\u2010less revascularization strategy using a combination of excimer laser and drug\u2010coated balloon for patients with acute coronary syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Ayako","family":"Harima","sequence":"first","affiliation":[{"name":"Department of Cardiology Hiroshima City Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-1508","authenticated-orcid":false,"given":"Akinori","family":"Sairaku","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima 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Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniomi","family":"Ohi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima City Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima City Hospital Hiroshima Japan"},{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima 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