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Furthermore, due to similarities with bare metal stents after drug elution, PF\u2010DES has been considered as particularly suitable for patients at high bleeding risk. A variety of PF\u2010DES platforms have been clinically tested. Despite their theoretical advantages, PF platforms showed comparable clinical outcomes with modern permanent\u2010 or biodegradable polymer\u2010based DES up to 5 years after implantation. Use of more biocompatible polymers on the modern DES platforms is one of the reasons therefore. Their improved safety profile allows already less intensive antithrombotic regimes after DES. 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