{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:05Z","timestamp":1787015525066,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left atrial appendage occlusion (LAAO) is a promising intervention for stroke prevention in patients with non\u2010valvular atrial fibrillation (NVAF). Early outcomes following LAAO have been published in many studies with variable results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This updated meta\u2010analysis aims to provide a summary of the early outcomes of LAAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline\/Pubmed, Ovid Journals, Clinical trials, Abstract meetings, Cochrane databases were searched from January 1st, 1999 to November 30th, 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included 49 studies involving 12\u2009415 patients. The median age was 73.5 years (IQR 72\u201075 years) and 43% were males. Hypertension and diabetes were present in 36% and 15% of the population, respectively. There was a prior history of stroke and congestive heart failure in 14% and 18% of the population, respectively. The median CHADS\n                      <jats:sub>2<\/jats:sub>\n                      score was 2.9 (IQR 2.6\u20103.3) and the median HASBLED score was 3.3 (IQR 3\u20104). LAAO implantation was successful in 96.3% of patients (95.40\u201097.08,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200976.1%). The pooled proportion of all\u2010cause mortality was 0.28% (0.19\u20100.38,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). The pooled proportion of all\u2010cause stroke was 0.31% (0.22\u20100.42,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20099.4%), major bleeding requiring transfusion was 1.71% (1.13\u20102.41,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200973.2%), and pericardial effusion was 3.25% (2.46\u20104.14,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200979%). Sub analysis of randomized clinical trials comparing LAAO devices to warfarin showed lower mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) with similar bleeding risk (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.20) with LAAO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis concludes that LAAO occlusion is a safe and effective stroke prevention strategy in patients with NVAF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joic.12502","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T18:12:38Z","timestamp":1519927958000},"page":"197-206","source":"Crossref","is-referenced-by-count":31,"title":["An updated systematic review and meta\u2010analysis of early outcomes after left atrial appendage occlusion"],"prefix":"10.1111","volume":"31","author":[{"given":"Charan","family":"Yerasi","sequence":"first","affiliation":[{"name":"St. Joseph's Hospital and Medical Center Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-3545","authenticated-orcid":false,"given":"Mohamad","family":"Lazkani","sequence":"additional","affiliation":[{"name":"University of Arizona Banner University Medical Center Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathik","family":"Kolluru","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University\/MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Miryala","sequence":"additional","affiliation":[{"name":"St. Francis Medical Center Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University\/MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Moole","sequence":"additional","affiliation":[{"name":"University of Illinois College of Medicine Peoria Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4443","authenticated-orcid":false,"given":"Abhishek C.","family":"Sawant","sequence":"additional","affiliation":[{"name":"State University of New York at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Arizona Banner University Medical Center Phoenix 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