{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:23:31Z","timestamp":1762867411681,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/11\/126\/29321"],"award-info":[{"award-number":["PG\/11\/126\/29321"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to compare using serial CMR, the quantity of AR and associated valve hemodynamics, following the first\u2010generation CoreValve (Medtronic, Minneapolis, MN) and the second\u2010generation Lotus valve (Boston Scientific, Natick, MA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Aortic regurgitation (AR) following Transcatheter Aortic Valve Replacement (TAVR) confers a worse prognosis and can be accurately quantified using cardiovascular magnetic resonance (CMR). Second generation valves have been specifically designed to reduce paravalvular AR and improve clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one patients (79.0\u2009\u00b1\u20097.7 years, 57% male) were recruited and imaged at three time points: immediately pre\u2010 and post\u2010TAVR, and at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CMR\u2010derived AR fraction immediately post\u2010TAVR was greater in the CoreValve compared to Lotus group (11.7\u2009\u00b1\u20098.4 vs. 4.3\u2009\u00b1\u20093.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), as was the frequency of \u2265moderate AR (9\/24 (37.5%) versus 0\/27, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). However, at 6 months AR fraction had improved significantly in the CoreValve group such that the two valve designs were comparable (6.4\u2009\u00b1\u20095.0 vs 5.6\u2009\u00b1\u20095.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.623), with no patient in either group having \u2265moderate AR. The residual peak pressure gradient immediately following TAVR was significantly lower with CoreValve compared to Lotus (14.1\u2009\u00b1\u20095.6 vs 25.4\u2009\u00b1\u200911.6\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), but again by 6 months the two valve designs were comparable (16.5\u2009\u00b1\u20099.4 vs 19.7\u2009\u00b1\u200910.5\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.332). There was no difference in the degree of LV reverse remodeling between the two valves at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immediately post\u2010TAVR, there was significantly less AR but a higher residual peak pressure gradient with the Lotus valve compared to CoreValve. However, at 6 months both devices had comparable valve hemodynamics and LV reverse remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12512","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T03:10:01Z","timestamp":1524712201000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular magnetic resonance assessment of 1st generation CoreValve and 2nd generation Lotus valves"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-6553","authenticated-orcid":false,"given":"Tarique Al","family":"Musa","sequence":"first","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhlaque","family":"Uddin","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Dobson","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Swoboda","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Garg","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R. J.","family":"Foley","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Malkin","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Plein","sequence":"additional","affiliation":[{"name":"Multidisciplinary Cardiovascular Research Centre &amp; The Division of Biomedical Imaging Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK"},{"name":"Leeds Teaching Hospitals NHS Trust Leeds General Infirmary Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Blackman","sequence":"additional","affiliation":[{"name":"Leeds 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