{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:45:56Z","timestamp":1781732756436,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to investigate the prevalence and impact of acute kidney injury (AKI) in elderly patients undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>AKI may complicate PCI and has been associated with worse outcomes. Data on AKI following PCI in elderly patients are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 458 elderly (\u226580 years) patients undergoing PCI at Charit\u00e9\u2014University Medicine Berlin between January 2009 and December 2014 were stratified according to the presence\/absence of AKI. The primary endpoint was all\u2010cause mortality. The secondary endpoint was rate of major adverse cardiovascular events (MACE), a composite of all\u2010cause mortality, non\u2010fatal myocardial infarction, non\u2010fatal stroke, and rehospitalization for heart failure. Median follow\u2010up was 280 (interquartile range 22\u20101190) days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 458 patients, 125 (27.3%) developed AKI following PCI. Age &gt;90 years, congestive heart failure, and C\u2010reactive protein at presentation emerged as independent predictors of AKI. All\u2010cause mortality was 20.0% and 8.4% in patients with and without AKI (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and corresponding rates of MACE were 39.2% and 26.4% (<jats:italic>P<\/jats:italic>\u2009=\u20090.01), respectively. The occurrence of AKI was associated with an increased risk of all\u2010cause mortality (adjusted HR 2.41, 95%CI 1.12\u20105.17, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and MACE (adjusted HR 1.75, 95%CI 1.15\u20102.67, <jats:italic>P<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AKI occurs in a third of elderly (\u226580 years) patients undergoing PCI and is associated with increased mortality. These findings underline the unmet clinical need to identify novel strategies for the prevention of AKI in this high\u2010risk patient subset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12547","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T13:10:23Z","timestamp":1533301823000},"page":"792-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impact of acute kidney injury in elderly (\u226580 years) patients undergoing percutaneous coronary intervention"],"prefix":"10.1111","volume":"31","author":[{"given":"David M.","family":"Leistner","sequence":"first","affiliation":[{"name":"Department of Cardiology Charit\u00e9\u2014University Medicine Berlin Campus Benjamin Franklin Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) Partner Site Berlin Berlin Germany"},{"name":"Berlin Institute of Health (BIH) Berlin 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