{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:06:18Z","timestamp":1792325178831,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our systematic review was to investigate the efficacy of coronary sinus (CS) reducer device in patients with refractory angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The CS reducer device provides a therapeutic option for patients with coronary artery disease who are not suitable for revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two independent investigators (GB and GT) systematically searched the Medline and Cochrane library databases for studies describing the efficacy and safety of the CS reducer in patients with refractory angina from January 1, 2000 until May 12, 2018 using the following terms: \u201ccoronary sinus (reducer OR reducing) device.\u201d Efficacy was defined as \u22651 unit improvement in the Canadian cardiovascular society (CCS) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search strategy provided six studies (five observational studies and one randomized clinical trial) with 196 patients. The CS reducer device was effective in 146\/186 (78.5%) patients. CCS score improved from 3.2 at baseline to 1.9 after 8.6 months of follow\u2010up. The efficacy of CS reducer device was also demonstrated as an improvement in Seattle Angina Questionnaire score, dobutamine echocardiography, thalium single\u2010photon emission computed tomography perfusion studies, 6\u2010min\u2010walk test and myocardial perfusion reserve index. Implantation failed in 4 of 196 (2%) patients and 5 patients (2.5%) had a complication during 30\u2010day follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CS reducer is a promising treatment option for patients with refractory angina who are not candidates for revascularization. However, larger randomized control trials with long\u2010term follow\u2010up are needed to elucidate its role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12560","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T08:08:45Z","timestamp":1536307725000},"page":"775-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The efficacy of coronary sinus reducer in patients with refractory angina\u2014A systematic review of the literature"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-9772","authenticated-orcid":false,"given":"George","family":"Bazoukis","sequence":"first","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil S.","family":"Brilakis","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Abbott Northwestern Hospital Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong  SAR P. R. China"},{"name":"Faculty of Medicine Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong Hong Kong, SAR P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos P.","family":"Letsas","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kitsoulis","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy\u2010Histology\u2010Embryology School of Medicine University of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Baranchuk","sequence":"additional","affiliation":[{"name":"Division of Cardiology Electrophysiology and Pacing Queen's University, Kingston General Hospital Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Sideris","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology Evangelismos General Hospital of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"First Cardiology Clinic Hippokration Hospital University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Stavrakis","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiovascular Section Heart Rhythm Institute University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960300008003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.22.1.34"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00042"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1401-98"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402556"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0862-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.061"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.06.062"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.251"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00626"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx486"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27549"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-017-0300-4"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joic.12560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:45:22Z","timestamp":1694760322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joic.12560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/joic.12560"],"URL":"https:\/\/doi.org\/10.1111\/joic.12560","archive":["Portico"],"relation":{},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}