{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:06Z","timestamp":1747186506035,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) for low gradient (LG) severe aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) remains an area of clinical uncertainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review identified 422 patients who underwent TAVR between September 4, 2014 and July 1, 2016. Procedural indication other than severe AS (<jats:italic>n<\/jats:italic>\u2009=\u200922) or LVEF <jats:styled-content>&lt;<\/jats:styled-content>50% (<jats:italic>n<\/jats:italic>\u2009=\u200998) were excluded. Outcomes were defined by valve academic research consortium two criteria when applicable and compared between LG (peak velocity &lt;4.0\u2009m\/s and mean gradient &lt;40 mmHg; <jats:italic>n<\/jats:italic>\u2009=\u200973) and high gradient (HG) (<jats:italic>n<\/jats:italic>\u2009=\u2009229) groups. The LG group was further categorized as low stroke volume index (SVI) (<jats:italic>n<\/jats:italic>\u2009=\u200941) or normal SVI (<jats:italic>n<\/jats:italic>\u2009=\u200932). Median follow\u2010up was 747 days [interquartile range 220\u20131013].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline thirty\u2010day mortality risk (LG 6.2% [3.8\u20138.1] vs HG 5.7% [4.1\u20137.4], <jats:italic>P<\/jats:italic>\u2009=\u20090.43) did not differ between groups. Short\u2010term outcomes, including procedural success rate (86.1% vs 88.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.53), peri\u2010procedural complications (intra\u2010procedural heart block: 6.8% vs 7.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.99; permanent pacemaker placement: 11.0% vs 13.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.69; moderate paravalvular regurgitation: 2.7% vs 1.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.60), and all\u2010cause in\u2010hospital mortality (2.7% vs 0.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.25) did not differ between LG and HG groups. On long\u2010term follow\u2010up, all\u2010cause mortality also did not differ between LG and HG groups (6.8% vs 10.0%, p<jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.33) or between the LG low SVI (9.8%), LG normal SVI (3.1%), and HG (10.0%) groups (p<jats:sub>log\u2010rank<\/jats:sub>\u2009=\u20090.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with preserved LVEF undergoing TAVR for severe AS with LG, including LG with low SVI, have no significant difference in adverse outcomes when compared to patients with HG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12561","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:33:58Z","timestamp":1536626038000},"page":"849-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes after transcatheter aortic valve replacement in patients with low versus high gradient severe aortic stenosis in the setting of preserved left ventricular ejection fraction"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-8001","authenticated-orcid":false,"given":"Binita","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology Veterans Affairs New York Harbor Health System and New York University (NYU) School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darien","family":"Paone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Redel\u2010Traub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umair","family":"Jangda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamed","family":"Saric","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Donnino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology Veterans Affairs New York Harbor Health System and New York University (NYU) School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezar","family":"Staniloae","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Benenstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology NYU School of Medicine New York New 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