{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:39:42Z","timestamp":1791203982126,"version":"4.2.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Aim of the study was to assess in\u2010hospital survival rate and the degree of myocardial recovery after MCS treatment (IABP or IMPELLA) at discharge and at 6 months in patients with AMI\u2010CS and planned early percutaneous revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>All studies on MCS for acute myocardial infarction related cardiogenic shock (AMI\u2010CS) focused on its impact on in\u2010hospital mortality; however, few data about its role on myocardial recovery are available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study on 64 patients: 36 patients (56%) received IABP and 28 (44%) Impella 2.5\/CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients treated with Impella were sicker compared to those treated with IABP as shown by a higher need of catecholamines (93% Impella vs 57% IABP,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and higher inotropic score before procedure: 8 (5\u201015) versus 4.5 (0\u20109),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02. In\u2010hospital survival and MCS\u2010related complications were comparable; hemolysis was more frequent in the Impella group (32% vs 0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Myocardial damage was lower in those patients who were implanted with IMPELLA before PCI: lower troponin peak [3831\u2009ng\/dL (1441\u20108436) vs 16\u2009581 (7802\u201023\u2009675),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004] and lower CPK peak [893 UI\/L (584\u20104082) vs 5797 (2483\u20109292)\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04]. Impella patients had higher LVEF at 6 months [45 (38\u201052) vs 40 (33\u201045)%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04]. LVEF increase at 6 months was statistically significant in both groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with higher myocardial recovery in patients supported with Impella (absolute delta\u2010LVEF increase 20% vs 10%\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac unloading with IMPELLA in ACS\u2010CS, especially if implanted before PCI, might provide lower myocardial damage and improved myocardial recovery which translates into significantly higher LVEF at 6 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joic.12569","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T20:38:38Z","timestamp":1542746318000},"page":"717-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The role of different mechanical circulatory support devices and their timing of implantation on myocardial damage and mid\u2010term recovery in acute myocardial infarction related cardiogenic shock"],"prefix":"10.1111","volume":"31","author":[{"given":"Marina","family":"Pieri","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Division of Cardiology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Oppizzi","sequence":"additional","affiliation":[{"name":"Division of Cardiology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Melisurgo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-833X","authenticated-orcid":false,"given":"Federico","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.17.1892"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.64"},{"key":"e_1_2_9_5_1","article-title":"Stent thrombosis: definitions, mechanisms and prevention","author":"Grouve E","year":"2007","journal-title":"E\u2010J Cardiol Pract"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_9_7_1","volume-title":"Nomenclature and criteria for diagnosis of diseases of the heart and great vessels","author":"Dolgin M","year":"1994"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.3.947585"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2226"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.069"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70241-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.260"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.2.190"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61783-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0119-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11150.1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.06.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.01.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20271"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.668"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoic.12569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joic.12569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:44:18Z","timestamp":1694745858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joic.12569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/joic.12569"],"URL":"https:\/\/doi.org\/10.1111\/joic.12569","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738326515.793576629","asserted-by":"object"}]},"ISSN":["0896-4327","1540-8183"],"issn-type":[{"value":"0896-4327","type":"print"},{"value":"1540-8183","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]},"assertion":[{"value":"2018-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}