{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:34:49Z","timestamp":1764794089795,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Interven Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives and Background<\/jats:title><jats:p>Polymer coatings of drug\u2010eluting stents (DES) may induce allergic reactions and inflammation, resulting in late\u2010acquired stent malapposition (LASM) with the risk of stent thrombosis. This study evaluated, if biodegradable polymer (BP) reduces the incidence of LASM compared to permanent polymer (PP) after treatment with newer generation DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Fifty patients with 59 lesions were randomized (2:1) to elective treatment with second generation PP\u2010DES (<jats:italic>n<\/jats:italic>\u2009=\u200932, 39 stents), either Everolimus\u2010eluting or Zotarolimus\u2010eluting stents, or with BP\u2010DES (Biolimus\u2010eluting stents [BES]; <jats:italic>n<\/jats:italic>\u2009=\u200918, 20 stents) and underwent optical coherence tomography directly after implantation and after 1 year. After implantation acute stent malappositions (ASM) were documented in 30 stents (51%) distributed to 22 stents treated with PP\u2010DES (56%) and 8 with BP\u2010DES (40%; n.s.). After 1 year, late stent malappositions (LSM) were detected in 14 stents (24 %); ASM persisted (APSM) in 9 stents after one year (7 PP\u2010DES\u201418%, 2 BES\u201410%), whereas ASM resolved in 21 stents. In addition, LASM was documented in nine stents including five stents without and four stents with additional APSM. All LASM were located in PP\u2010DES (<jats:italic>n<\/jats:italic>\u2009=\u20099; 23%), none in BP\u2010DES (<jats:italic>P<\/jats:italic>\u2009=\u20090.022). Compared to the reference lumen area, in\u2010stent lumen area of stents without LASM was smaller due to neointimal hyperplasia (<jats:italic>P<\/jats:italic>\u2009=\u20090.021), whereas in\u2010stent lumen area at maximum LASM of stents with LASM was larger due to positive remodeling (<jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion the use of BP\u2010DES reduced the occurrence of LASM due to positive remodeling compared to second generation PP\u2010DES.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joic.12572","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T08:20:05Z","timestamp":1543306805000},"page":"780-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence of late\u2010acquired stent malapposition of drug eluting stents with second generation permanent and biodegradable polymer coatings\u2014A prospective, randomized comparison using optical coherence tomography"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0155-9370","authenticated-orcid":false,"given":"Christian","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II Cardiology, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Gangl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Cardiology, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dalos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Cardiology, Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Delle\u2010Karth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Cardiology, Hospital of Hietzing Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Neunteufl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Cardiology, University Hospital of Krems Krems an der Donau Austria"},{"name":"Karl Landsteiner Private University for Health Sciences Krems an der Donau Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Cardiology, Medical University of Vienna Vienna Austria"},{"name":"Department of Internal Medicine I Cardiology and Nephrology, Hospital of St. John of God Eisenstadt Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.058560"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.693739"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv711"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019071"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.12.205"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-012-0039-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.854398"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116202.41966.D4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp480"},{"key":"e_1_2_8_12_1","unstructured":"AdriaenssensT UghiGJ DuboisC et al. 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