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The Swedish Obese Subjects (\n                    <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>\n                    ) study is the first long\u2010term, prospective, controlled trial to provide information on the effects of bariatric surgery on the incidence of these objective endpoints. The\n                    <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>\n                    study involved 2010 obese subjects who underwent bariatric surgery [gastric bypass (13%), banding (19%) and vertical banded gastroplasty (68%)] and 2037 contemporaneously matched obese control subjects receiving usual care. The age of participants was 37\u201360\u00a0years and body mass index (\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    ) was \u226534\u00a0kg\u00a0m\n                    <jats:sup>\u22122<\/jats:sup>\n                    in men and \u226538\u00a0kg\u00a0m\n                    <jats:sup>\u22122<\/jats:sup>\n                    in women. Here, we review the key\n                    <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>\n                    study results published between 2004 and 2012. Follow\u2010up periods varied from 10 to 20\u00a0years in different reports. The mean changes in body weight after 2, 10, 15 and 20\u00a0years were \u221223%, \u221217%, \u221216% and \u221218% in the surgery group and 0%, 1%, \u22121% and \u22121% in the control group respectively. Compared with usual care, bariatric surgery was associated with a long\u2010term reduction in overall mortality (primary endpoint) [adjusted hazard ratio (\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    )\u00a0=\u00a00.71, 95% confidence interval (\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) 0.54\u20130.92;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.01] and decreased incidences of diabetes (adjusted\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    =0.17;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.001), myocardial infarction (adjusted\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a00.71;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.02), stroke (adjusted\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    =0.66;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.008) and cancer (women: adjusted\n                    <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                    \u00a0=\u00a00.58;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.0008; men: n.s.]. The diabetes remission rate was increased severalfold at 2\u00a0years [adjusted odds ratio (\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    )\u00a0=\u00a08.42;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001] and 10\u00a0years (adjusted\n                    <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                    \u00a0=\u00a03.45;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). Whereas high insulin and\/or high glucose at baseline predicted favourable treatment effects, high baseline\n                    <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                    did not, indicating that current selection criteria for bariatric surgery need to be revised.\n                  <\/jats:p>","DOI":"10.1111\/joim.12012","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T09:47:20Z","timestamp":1365760040000},"page":"219-234","source":"Crossref","is-referenced-by-count":1680,"title":["Review of the key results from the Swedish Obese Subjects (\n                    <scp>SOS<\/scp>\n                    ) trial \u2013 a prospective controlled intervention study of bariatric surgery"],"prefix":"10.1111","volume":"273","author":[{"given":"L.","family":"Sj\u00f6str\u00f6m","sequence":"first","affiliation":[{"name":"From the The SOS secretariat Department of Molecular and Clinical Medicine Institute of Medicine The Sahlgrenska Academy The University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.08.050"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.39"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.10.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.351"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62037-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"516S","DOI":"10.1093\/ajcn\/55.2.516s","article-title":"Mortality of severly obese subjects","volume":"55","author":"Sj\u00f6str\u00f6m L","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055643"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60318-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.187"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198811033191801"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1997.tb00572.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035622"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.282"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490150097031"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/24.4.694"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01010.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp162"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.04.018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.09.039"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00023"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117386"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009843"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.10.1499"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009680"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010261"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60766-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005656"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.13.1547"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003114"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066603"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000137343.63376.19"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.06.014"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(97)80112-6"},{"key":"e_1_2_8_35_1","first-page":"465","article-title":"Swedish obese subjects (SOS). 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