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The different clinical variants of orthostatic intolerance include initial, classical and delayed\n                    <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                    as well as postural tachycardia syndrome. Orthostatic instability may induce syncopal attacks either alone or in combination with other mechanisms, and is often dismissed as a precipitating factor. Moreover, prevalent\n                    <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                    is an independent risk factor for all\u2010cause mortality and cardiovascular morbidity, and the majority of patients with\n                    <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                    are asymptomatic or have few nonspecific symptoms. Management of symptomatic orthostatic intolerance includes both nonpharmacological and pharmacological methods, but it is not always successful and may lead to complications. Future studies of\n                    <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                    should focus on mechanisms that lead to neurogenic and nonneurogenic\n                    <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                    , novel diagnostic methods and more effective therapeutic modalities.\n                  <\/jats:p>","DOI":"10.1111\/joim.12021","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T09:35:19Z","timestamp":1365759319000},"page":"322-335","source":"Crossref","is-referenced-by-count":128,"title":["Syndromes of orthostatic intolerance: a hidden danger"],"prefix":"10.1111","volume":"273","author":[{"given":"A.","family":"Fedorowski","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Clinical Research Center Lund University Malm\u00f6 Sweden"},{"name":"Arrhythmia Department Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Unit of Clinical Physiology and Nuclear Medicine Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Clinical Research Center Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1994.tb04977.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70088-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1116"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.99"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00260.2002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01248.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39412.525243.BE"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522010-00004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2005.04223.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(25)90007-5"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Abnormal static circulatory phenomena and their symptoms: arterial orthostatic anemia as neglected clinical picture","volume":"33","author":"Bjure A","year":"1927","journal-title":"Upsala L\u00e4karef F\u00f6rh"},{"key":"e_1_2_8_13_1","first-page":"17","article-title":"L'hypotension orthostatique","volume":"40","author":"Laubry C","year":"1932","journal-title":"Presse M\u00e9d"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(37)90926-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(38)80064-0"},{"key":"e_1_2_8_16_1","first-page":"126","article-title":"Case report of orthostatic hypotension","volume":"33","author":"Farmer HE","year":"1941","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1940.02810510038010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103398"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.03840110025004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.3.363"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91681-0"},{"key":"e_1_2_8_22_1","first-page":"117","article-title":"Orthostatic hypotension","volume":"56","author":"Thomas JE","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archinte.1984.00350160129021","article-title":"Orthostatic hypotension. 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