{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T17:22:22Z","timestamp":1782062542281,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society","award":["CAN 2008\/562"],"award-info":[{"award-number":["CAN 2008\/562"]}]},{"name":"Swedish Cancer Society","award":["10 0333"],"award-info":[{"award-number":["10 0333"]}]},{"DOI":"10.13039\/100001543","name":"Children's Cancer Foundation","doi-asserted-by":"crossref","award":["PROJ09\/093"],"award-info":[{"award-number":["PROJ09\/093"]}],"id":[{"id":"10.13039\/100001543","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001543","name":"Children's Cancer Foundation","doi-asserted-by":"crossref","award":["PROJ 09\/014"],"award-info":[{"award-number":["PROJ 09\/014"]}],"id":[{"id":"10.13039\/100001543","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["K2008-64X-05971-28-3"],"award-info":[{"award-number":["K2008-64X-05971-28-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007231","name":"Cancer Society in Stockholm","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007231","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To our knowledge, no randomized toxicity studies have been conducted to compare myeloablative conditioning (MAC<\/jats:styled-content>) and reduced\u2010intensity conditioning (RIC<\/jats:styled-content>) in allogeneic haematopoietic stem cell transplantation (HSCT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Adult patients \u226460\u00a0years of age with myeloid leukaemia were randomly assigned (1\u00a0:\u00a01) to treatment with RIC<\/jats:styled-content> (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>18) or MAC<\/jats:styled-content> (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>19) in this Phase II<\/jats:styled-content> single\u2010centre toxicity study.<\/jats:p><\/jats:sec>Results<\/jats:title>There was a maximum median mucositis grade of 1 in the RIC<\/jats:styled-content> group compared with 4 in the MAC<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). Haemorrhagic cystitis occurred in eight of the patients in the MAC<\/jats:styled-content> group and none in the RIC<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). Results of renal and hepatic tests did not differ significantly between the two groups. RIC<\/jats:styled-content>\u2010treated patients had faster platelet engraftment (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01) and required fewer erythrocyte and platelet transfusions (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and less total parenteral nutrition (TPN<\/jats:styled-content>) than those treated with MAC<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). Cytomegalovirus (CMV<\/jats:styled-content>) infection was more common in the MAC<\/jats:styled-content> group (14\/19) than in the RIC<\/jats:styled-content> group (6\/18) (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02). Donor chimerism was similar in the two groups with regard to CD<\/jats:styled-content>19 and CD<\/jats:styled-content>33, but was delayed for CD<\/jats:styled-content>3 in the RIC<\/jats:styled-content> group. Five\u2010year transplant\u2010related mortality (TRM<\/jats:styled-content>) was approximately 11% in both groups, and rates of relapse and survival were not significantly different. Patients in the MAC<\/jats:styled-content> group with intermediate cytogenetic acute myeloid leukaemia had a 3\u2010year survival of 73%, compared with 90% among those in the RIC<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Reduced\u2010intensity conditioning had several advantages compared with MAC<\/jats:styled-content>, including less mucositis, less haemorrhagic cystitis, faster platelet engraftment, the need for fewer transfusions and less TPN<\/jats:styled-content>, and fewer CMV<\/jats:styled-content> infections. Both regimens were tolerated and TRM<\/jats:styled-content> was low.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12056","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T14:02:40Z","timestamp":1365775360000},"page":"153-162","source":"Crossref","is-referenced-by-count":42,"title":["A prospective randomized toxicity study to compare reduced\u2010intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"274","author":[{"given":"O.","family":"Ringd\u00e9n","sequence":"first","affiliation":[{"name":"Division of Therapeutic Immunology and Centre for Allogeneic Stem Cell Transplantation Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Erkers","sequence":"additional","affiliation":[{"name":"Division of Therapeutic Immunology and Centre for Allogeneic Stem Cell Transplantation Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Aschan","sequence":"additional","affiliation":[{"name":"Centre for Allogeneic Stem Cell Transplantation Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Garming\u2010Legert","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Le Blanc","sequence":"additional","affiliation":[{"name":"Hematology Centre Karolinska University Hospital Huddinge Karolinska Institutet Stockholm 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