{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:26:01Z","timestamp":1770956761403,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Swedish Society of Medicine"},{"name":"Swedish Research Council - Medicine","award":["522-2A09-195"],"award-info":[{"award-number":["522-2A09-195"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of this study was to examine mortality in patients with both type 1 diabetes (T<\/jats:styled-content>1D<\/jats:styled-content>) and coeliac disease (CD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Between 1969 and 2008, we identified individuals with CD<\/jats:styled-content> through biopsy reports from all pathology departments (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>28) in S<\/jats:styled-content>weden. T<\/jats:styled-content>1D<\/jats:styled-content> was defined as a diagnosis of diabetes recorded in the S<\/jats:styled-content>wedish N<\/jats:styled-content>ational P<\/jats:styled-content>atient R<\/jats:styled-content>egister between 1964 and 2009 in individuals aged \u226430\u00a0years. During follow\u2010up, we identified 960 patients with both T<\/jats:styled-content>1D<\/jats:styled-content> and CD<\/jats:styled-content>. For each individual with T<\/jats:styled-content>1D<\/jats:styled-content> and CD<\/jats:styled-content>, we selected up to five subjects with T<\/jats:styled-content>1D<\/jats:styled-content> alone (i.e. no CD<\/jats:styled-content>), matched for sex, age and calendar period of diagnosis, as the reference group (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>4608). Using a stratified C<\/jats:styled-content>ox regression analysis with CD<\/jats:styled-content> as a time\u2010dependent covariate, we estimated the risk of death in patients with both T<\/jats:styled-content>1D<\/jats:styled-content> and CD<\/jats:styled-content> compared with those with T<\/jats:styled-content>1D<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>Results<\/jats:title>Stratifying for time since CD<\/jats:styled-content> diagnosis, CD<\/jats:styled-content> was not a risk factor for death in patients with T<\/jats:styled-content>1D<\/jats:styled-content> during the first 5\u00a0years after CD<\/jats:styled-content> diagnosis [hazard ratio (HR<\/jats:styled-content>) 0.87, 95% confidence interval (CI<\/jats:styled-content>) 0.43\u20131.73], but thereafter the HR<\/jats:styled-content> for mortality increased as a function of follow\u2010up time (5 to <10\u00a0years, HR<\/jats:styled-content> 1.44, 95% CI<\/jats:styled-content> 0.74\u20132.79; 10 to <15\u00a0years, HR<\/jats:styled-content> 1.88, 95% CI<\/jats:styled-content> 0.81\u20134.36). Having a CD<\/jats:styled-content> diagnosis for \u226515\u00a0years was associated with a 2.80\u2010fold increased risk of death in individuals with T<\/jats:styled-content>1D<\/jats:styled-content> (95% CI<\/jats:styled-content> 1.28\u20136.12).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A diagnosis of CD<\/jats:styled-content> for \u226515\u00a0years increases the risk of death in patients with T<\/jats:styled-content>1D<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12092","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T16:23:24Z","timestamp":1369326204000},"page":"273-280","source":"Crossref","is-referenced-by-count":45,"title":["Long\u2010term coeliac disease influences risk of death in patients with type 1 diabetes"],"prefix":"10.1111","volume":"274","author":[{"given":"K.","family":"Mollazadegan","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine, Solna Karolinska Institutet Stockholm Sweden"},{"name":"St. Erik Eye Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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