{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:46:10Z","timestamp":1791301570341,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LA-SER"},{"name":"Sanofi Pasteur MSD"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>The aim of this study was to investigate whether the quadrivalent human papillomavirus (HPV<\/jats:styled-content>) vaccine Gardasil is associated with a change in the risk of autoimmune disorders (AD<\/jats:styled-content>s) in young female subjects.<\/jats:p><\/jats:sec>Design<\/jats:title>Systematic case\u2013control study of incident AD<\/jats:styled-content>s associated with quadrivalent HPV<\/jats:styled-content> vaccination in young women across France.<\/jats:p><\/jats:sec>Participants and setting<\/jats:title>A total of 113 specialised centres recruited (from December 2007 to April 2011) females aged 14\u201326\u00a0years with incident cases of six types of AD<\/jats:styled-content>s: idiopathic thrombocytopenic purpura (ITP<\/jats:styled-content>), central demyelination\/multiple sclerosis (MS<\/jats:styled-content>), Guillain\u2013Barr\u00e9 syndrome, connective tissue disorders (systemic lupus erythematosus, rheumatoid arthritis\/juvenile arthritis), type 1 diabetes mellitus and autoimmune thyroiditis. Control subjects matched to cases were recruited from general practice.<\/jats:p><\/jats:sec>Analysis<\/jats:title>Multivariate conditional logistic regression analysis; factors included age, geographical origin, smoking, alcohol consumption, use of oral contraceptive(s) or vaccine(s) other than Gardasil received within 24\u00a0months before the index date and personal\/family history of AD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 211 definite cases of AD<\/jats:styled-content>s were matched to 875 controls. The adjusted odds ratio (OR<\/jats:styled-content>) for any quadrivalent HPV<\/jats:styled-content> vaccine use was 0.9 [95% confidence interval (CI<\/jats:styled-content>) 0.5\u20131.5]. The individual OR<\/jats:styled-content>s were 1.0 (95% CI<\/jats:styled-content> 0.4\u20132.6) for ITP<\/jats:styled-content>, 0.3 (95% CI<\/jats:styled-content> 0.1\u20130.9) for MS<\/jats:styled-content>, 0.8 (95% CI<\/jats:styled-content> 0.3\u20132.4) for connective disorders and 1.2 (95% CI<\/jats:styled-content> 0.4\u20133.6) for type 1 diabetes. No exposure to HPV<\/jats:styled-content> vaccine was observed in cases with either Guillain\u2013Barr\u00e9 syndrome or thyroiditis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>No evidence of an increase in the risk of the studied AD<\/jats:styled-content>s was observable following vaccination with Gardasil within the time periods studied. There was insufficient statistical power to allow conclusions to be drawn regarding individual AD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12155","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T10:07:34Z","timestamp":1383905254000},"page":"398-408","source":"Crossref","is-referenced-by-count":121,"title":["Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects"],"prefix":"10.1111","volume":"275","author":[{"given":"L.","family":"Grimaldi\u2010Bensouda","sequence":"first","affiliation":[{"name":"LA\u2010SER Paris France"},{"name":"Conservatoire National des Arts et M\u00e9tiers (CNAM) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Guillemot","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology and Infectious Diseases Unit (PhEMI) Institut Pasteur Paris France"},{"name":"INSERM U657 Paris France"},{"name":"Faculty of 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