{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:40:40Z","timestamp":1784896840133,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"C\u00e1tedra Asisa-Universidad Europea de Madrid","award":["CAT001206C"],"award-info":[{"award-number":["CAT001206C"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To study the factors associated with choice of therapy and prognosis in octogenarians with severe symptomatic aortic stenosis (AS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Study Design<\/jats:title>Prospective, observational, multicenter registry. Centralized follow\u2010up included survival status and, if possible, mode of death and K<\/jats:styled-content>atz index.<\/jats:p><\/jats:sec>Setting<\/jats:title>Transnational registry in S<\/jats:styled-content>pain.<\/jats:p><\/jats:sec>Subjects<\/jats:title>We included 928 patients aged \u226580\u00a0years with severe symptomatic AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Aortic\u2010valve replacement (AVR<\/jats:styled-content>), transcatheter aortic\u2010valve implantation (TAVI<\/jats:styled-content>) or conservative therapy.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>All\u2010cause death.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age was 84.2\u00a0\u00b1\u00a03.5\u00a0years, and only 49.0% were independent (K<\/jats:styled-content>atz index A<\/jats:styled-content>). The most frequent planned management was conservative therapy in 423 (46%) patients, followed by TAVI<\/jats:styled-content> in 261 (28%) and AVR<\/jats:styled-content> in 244 (26%). The main reason against recommending AVR<\/jats:styled-content> in 684 patients was high surgical risk [322 (47.1%)], other medical motives [193 (28.2%)], patient refusal [134 (19.6%)] and family refusal in the case of incompetent patients [35 (5.1%)]. The mean time from treatment decision to AVR<\/jats:styled-content> was 4.8\u00a0\u00b1\u00a04.6\u00a0months and to TAVI<\/jats:styled-content> 2.1\u00a0\u00b1\u00a03.2\u00a0months, P<\/jats:italic>\u00a0<\u00a00.001. During follow\u2010up (11.2\u201338.9\u00a0months), 357 patients (38.5%) died. Survival rates at 6, 12, 18 and 24\u00a0months were 81.8%, 72.6%, 64.1% and 57.3%, respectively. Planned intervention, adjusted for multiple propensity score, was associated with lower mortality when compared with planned conservative treatment: TAVI H<\/jats:styled-content>azard ratio (HR<\/jats:styled-content>) 0.68 (95% confidence interval [CI<\/jats:styled-content>] 0.49\u20130.93; P<\/jats:italic>\u00a0=\u00a00.016) and AVR HR<\/jats:styled-content> 0.56 (95% CI<\/jats:styled-content> 0.39\u20130.8; P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Octogenarians with symptomatic severe AS<\/jats:styled-content> are frequently managed conservatively. Planned conservative management is associated with a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12174","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T11:47:17Z","timestamp":1386589637000},"page":"608-620","source":"Crossref","is-referenced-by-count":47,"title":["Prospective registry of symptomatic severe aortic stenosis in octogenarians: a need for intervention"],"prefix":"10.1111","volume":"275","author":[{"given":"M.","family":"Mart\u00ednez\u2010Sell\u00e9s","sequence":"first","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n y Universidad Europea de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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