{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:08:44Z","timestamp":1777097324920,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Swedish Research Council Formas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Research Council for Health, Working Life, and Welfare"},{"name":"Swedish Research Council\/Committee for Infrastructure"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The potentially beneficial effects of fish consumption on stroke may be modified by major food contaminants in fish. Polychlorinated biphenyls (<jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content>s) in particular are proposed to play a role in the aetiology of stroke. The aim of this study was to assess the association between dietary <jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content> exposure and stroke risk with the intake of long\u2010chain omega\u20103 fish fatty acids and fish consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The prospective population\u2010based <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wedish <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ammography <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohort was examined. It was comprised of 34\u00a0591 women free of cardiovascular diseases and cancer at baseline in 1997 and followed up for 12\u00a0years. Validated estimates of dietary <jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content> exposure were obtained via a food frequency questionnaire at baseline. Incident cases of stroke were ascertained through register linkage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 12\u00a0years of follow\u2010up (397\u00a0309 person\u2010years), there were 2015 incident cases of total stroke (1532 ischaemic strokes, 216 intracerebral haemorrhages, 94 subarachnoid haemorrhages and 173 unspecified strokes). Multivariable\u2010adjusted relative risks (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>), controlled for known stroke risk factors and fish consumption, were 1.67 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.29\u20132.17] for total stroke, 1.61 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.19\u20132.17) for ischaemic stroke and 2.80 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.42\u20135.55) for haemorrhagic stroke for women in the highest quartile of dietary <jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content> exposure (median 288\u00a0ng\u00a0day<jats:sup>\u22121<\/jats:sup>) compared with women in the lowest quartile (median 101\u00a0ng\u00a0day<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dietary exposure to <jats:styled-content style=\"fixed-case\">PCB<\/jats:styled-content>s was associated with an increased stroke risk in women, especially haemorrhagic stroke. The results provide important information regarding the risk\u2010benefit analysis of fish consumption, particularly for cerebrovascular disease prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12194","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T06:18:31Z","timestamp":1389853111000},"page":"248-259","source":"Crossref","is-referenced-by-count":42,"title":["Dietary exposure to polychlorinated biphenyls is associated with increased risk of stroke in women"],"prefix":"10.1111","volume":"276","author":[{"given":"C.","family":"Bergkvist","sequence":"first","affiliation":[{"name":"Unit of Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kippler","sequence":"additional","affiliation":[{"name":"Unit of Nutritional Epidemiology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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