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These criteria both aim to support a clinical diagnosis with <jats:italic>in vivo<\/jats:italic> evidence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> pathology, using imaging methods and detection of biofluid biomarkers, and emphasize an aetiological diagnosis even in the prodromal stages of the disorder. Nonetheless, there are substantial differences in these two sets of criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international group of investigators with experience in the clinical diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> met at the Key Symposium in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tockholm, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden on 6 &amp; 7 December 2012, to develop recommendations to harmonize these criteria. The group was led by individuals who were integral to the development of both the <jats:styled-content style=\"fixed-case\">IWG<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">NIA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> criteria. The similarities and differences between the two sets of criteria were identified and open discussion focused on ways to resolve the differences and thus yield a harmonized set of criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on both published evidence as well as the group's collective clinical experience, the group was tasked with achieving consensus, if not unanimity, as it developed recommendations for harmonized clinical diagnostic criteria for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The recommendations are to: (i) define <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> as a brain disorder, regardless of clinical status; (ii) refer to the clinically expressed disorder, including its prodromal stages, as <jats:italic>symptomatic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content><\/jats:italic>; (iii) after the successful completion of standardization efforts, consider incorporating biomarkers into diagnostic algorithms for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>; and (iv) allow nonamnestic, atypical presentations to be included as <jats:italic>symptomatic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content><\/jats:italic>, especially when there is supportive biomarker evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12199","type":"journal-article","created":{"date-parts":[[2014,3,8]],"date-time":"2014-03-08T22:34:56Z","timestamp":1394318096000},"page":"204-213","source":"Crossref","is-referenced-by-count":90,"title":["Harmonized diagnostic criteria for Alzheimer's disease: recommendations"],"prefix":"10.1111","volume":"275","author":[{"given":"J. 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