{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:02Z","timestamp":1790617202672,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Orthostatic hypotension, a condition that mostly affects \u2018oldest\u2010old\u2019 (i.e. \u226580\u00a0years) adults, is primarily explained by age\u2010related dysfunction of blood pressure control. Vitamin D may contribute to blood pressure control. The aim of this study was to determine whether vitamin D deficiency is associated with orthostatic hypotension in oldest\u2010old adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectional analysis at baseline of the\n                      <jats:styled-content style=\"fixed-case\">EPIDOS<\/jats:styled-content>\n                      study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      Five\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      rench areas.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 329 community\u2010dwelling oldest\u2010old women (mean age 83.3\u00a0\u00b1\u00a00.2\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes measures<\/jats:title>\n                    <jats:p>\n                      Orthostatic hypotension was defined as a systolic blood pressure drop of \u226520\u00a0mmHg and\/or a diastolic blood pressure drop of \u226510\u00a0mmHg within 3\u00a0min of standing. Vitamin D deficiency was defined as a serum 25\u2010hydroxyvitamin D (25O\n                      <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>\n                      ) concentration \u226410\u00a0ng\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      . Covariates included in the models were age, body mass index, diabetes mellitus, supine mean arterial pressure, number of drugs taken per day, use of antihypertensive or psychoactive drugs, cognition, quadriceps strength, current smoking, alcohol consumption, serum concentrations of parathyroid hormone, calcium and creatinine and season of testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Diastolic orthostatic hypotension was observed more often among women with vitamin D deficiency (19.2%) compared to those without (10.0%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). There was an inverse linear association between 25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      concentration and change in diastolic blood pressure after 3\u00a0min of standing (adjusted \u03b2\u00a0=\u00a0\u22120.07,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.046). Similarly, 25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      deficiency was associated with orthostatic hypotension [adjusted odds ratio (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ) 3.36,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004], specifically with diastolic orthostatic hypotension (adjusted\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      3.81,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      deficiency was associated with orthostatic hypotension in oldest\u2010old women, due to a greater drop in diastolic blood pressure on standing. This finding may lead to better understanding of the pathophysiology of falls in oldest\u2010old adults with vitamin D deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.12201","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T09:45:46Z","timestamp":1390211146000},"page":"285-295","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin\n                    <scp>D<\/scp>\n                    deficiency is associated with orthostatic hypotension in oldest\u2010old women"],"prefix":"10.1111","volume":"276","author":[{"given":"C.","family":"Annweiler","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Angers University Hospital Angers France"},{"name":"UPRES EA4638 University of Angers UNAM Angers France"},{"name":"Robarts Research Institute The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010M.","family":"Schott","sequence":"additional","affiliation":[{"name":"Department of Medical Information Lyon University Hospital University Hospital University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Rolland","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Institut du Vieillissement Toulouse University Hospital Toulouse France"},{"name":"Inserm Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Angers University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/52B.Special_Issue.1"},{"key":"e_1_2_9_3_1","volume-title":"Improving Later Life: Understanding the Oldest old","author":"Davidson S","year":"2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.11.M667"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.02.023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.5.M273"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.3.273"},{"key":"e_1_2_9_8_1","first-page":"689","article-title":"What is the most relevant definition of orthostatic hypotension: systolic blood pressure drop, diastolic blood pressure drop, or both?","volume":"100","author":"Duron E","year":"2007","journal-title":"Arch Mal Coeur Vaiss"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.3.B115"},{"key":"e_1_2_9_10_1","first-page":"259","article-title":"Vitamin D in the elderly: 5 points to remember","volume":"9","author":"Annweiler C","year":"2011","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1867-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1681\/ASN.V133621","article-title":"Synthesis of 1,25\u2010dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion","volume":"13","author":"Zehnder D","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000160353.27927.70"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215219"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000025269.60668.0F"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2632"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0423"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328010ca18"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318570"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01440-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.80"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"e_1_2_9_23_1","volume-title":"Hypertension Primer: The Essentials of High Blood Pressure. 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