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Recent advances in understanding the biology of <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>tb<\/jats:italic>) infection and the immune response of the infected host have led to the development of several new vaccines, a number of which are already undergoing clinical trials. These include pre\u2010exposure prime vaccines, which could replace bacille <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>almette\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>u\u00e9rin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>), and pre\u2010exposure booster vaccines given in addition to <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>. Infants are the target population of these two types of vaccines. In addition, several postexposure vaccines given during adolescence or adult life, in addition to <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> as a priming vaccine during infancy, are undergoing clinical testing. Therapeutic vaccines are currently being assessed for their potential to cure active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> as an adjunct to chemotherapy. <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> replacement vaccines are viable recombinant <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> or double\u2010deletion mutants of <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>tb<\/jats:italic>. All booster vaccines are composed of one or several antigens, either expressed by viral vectors or formulated with adjuvants. Therapeutic vaccines are killed mycobacterial preparations. Finally, multivariate biomarkers and biosignatures are being generated from high\u2010throughput data with the aim of providing better diagnostic tools to specifically determine <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> progression. Here, we provide a technical overview of these recent developments as well of the relevant computational approaches and highlight the obstacles that still need to be overcome.<\/jats:p>","DOI":"10.1111\/joim.12212","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T16:25:11Z","timestamp":1395073511000},"page":"467-480","source":"Crossref","is-referenced-by-count":80,"title":["Recent advances towards tuberculosis control: vaccines and biomarkers"],"prefix":"10.1111","volume":"275","author":[{"suffix":"3rd","given":"J.","family":"Weiner","sequence":"first","affiliation":[{"name":"Department of Immunology Max Planck Institute for Infection Biology Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H. 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