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Key interventions to control malaria include prompt and effective treatment with artemisinin\u2010based combination therapies, use of insecticidal nets by individuals at risk and active research into malaria vaccines. Protection against malaria through vaccination was demonstrated more than 30\u00a0years ago when individuals were vaccinated via repeated bites by <jats:italic>Plasmodium falciparum<\/jats:italic>\u2010infected and irradiated but still metabolically active mosquitoes. However, vaccination with high doses of irradiated sporozoites injected into humans has long been considered impractical. Yet, following recent success using whole\u2010organism vaccines, the approach has received renewed interest; it was recently reported that repeated injections of irradiated sporozoites increased protection in 80 vaccinated individuals. Other approaches include subunit malaria vaccines, such as the current leading candidate <jats:styled-content style=\"fixed-case\">RTS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> (consisting of fusion between a portion of the <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic>\u2010derived circumsporozoite protein and the hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> surface antigen), which has been demonstrated to induce reasonably good protection. Although results have been encouraging, the level of protection is generally considered to be too low to achieve eradication of malaria. There is great interest in developing new and better formulations and stable delivery systems to improve immunogenicity. In this review, we will discuss recent strategies to develop efficient malaria vaccines.<\/jats:p>","DOI":"10.1111\/joim.12223","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T16:25:16Z","timestamp":1395073516000},"page":"456-466","source":"Crossref","is-referenced-by-count":93,"title":["The path of malaria vaccine development: challenges and perspectives"],"prefix":"10.1111","volume":"275","author":[{"given":"C.","family":"Arama","sequence":"first","affiliation":[{"name":"Malaria Research and Training Center University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali"},{"name":"Department of Molecular Biosciences The Wenner\u2010Gren Institute Stockholm University Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Troye\u2010Blomberg","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences The Wenner\u2010Gren Institute Stockholm University Stockholm 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